Electrochemical Reduction Behaviour of Zileuton
at a Dropping Mercury Electrode by Polarography
N. Y. SREEDHAR, M. SANKARA NAYAK, K. SRINIVASA PRASAD,
P. R. PRASAD and C. NAGESWAR REDDY
Electroanalytical Lab, Department of Chemistry,
Sri Venkateswara University, Tirupati, A.P, India.
Received 27 March 2009 / Revised 3 June 2009/Accepted 1 August 2009
Abstract: Electrochemical behaviour of anticancer drug zileuton was investigated by direct current polarography (DCP) and differential pulse polarography using a dropping mercury electrode (DME) as working electrode and Ag/AgCl reference electrode in universal buffer of pH range from 2.0 to 12.0. The drug was extracted from the dosage forms in dimethyl formamide (DMF). Kinetic parameters such as diffusion co-efficient (D) and heterogeneous forward rate constants (k0f,h) are evaluated and reported. The differential pulse polarographic method has been developed for the determination of this drug in pharmaceutical formulations.
Keywords: Zileuton, Polarography, Dropping Mercury Electrode (DME).
 Corresponding author email id
sankarmude@yahoo.co.in
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