The reliance of mankind on synthetic pesticide, particularly dichloro diphenyl-trichloro ethane (DDT) reached its zenith during 1950s-60s, since the first application during second world War. But very soon it faced a serious scientific opposition due to its bio-magnifying nature and was banned in 1970s in most part of world with certain exceptional usage in health control programmes. Although, the pesticidal activity range and economic viability of DDT has never been questioned and still there are several voices to bring back DDT. To answer this controversy is the search for new DDT like pesticide with similar pesticidal efficacy and lower ecological accumulative effects. Recent advances in computer aided molecular design has provided us very robust, economic and time and labour saving tool to design and develop new chemical entities with pesticidal activity similar to DDT and has good commercial prospects as well. The present paper reviews the brief history of DDT and the developments in computational and molecular design methods to rejuvenate the era of new pesticide research.
DDT, Molecular modelling, Pesticide design, Voltage gated sodium channel