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  • Chem Sci Trans., 2014, 3(3),  pp 1156-1162  

    DOI:10.7598/cst2014.771

    Research Article

    Spectrophotometric Methods for the Quantitative Estimation of Paliperidone in Formulations

  • UMAMAHESWAR KORRAPATI and RAMBABU CHINTALA*
  • Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur, Andhra Pradesh, India
  • Abstract

    Two simple, sensitive and economical spectrophotometric methods have been developed and validated for the determination of paliperidone in pharmaceutical dosage forms. The methods were based on the formation of colored complex of Paliperidone with different reagents. The absorbance of the formed colored complex is measured at the wavelength of maximum absorbance of the complex 665 nm and 555 nm respectively against the reagent blank treated similarly. These methods have different linearity ranges observed in the concentration ranges of 1-6 and 10-60 μg/mL with correlation coefficient of 0.998 for both the methods. Statistical analysis indicates that the proposed methods are reproducible and selective for the estimation of Paliperidone in bulk drug and in its tablet dosage form.

    Keywords

    Paliperidone, Spectrophotometric Methods, Isatin, Chloranilic acid

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