Two accurate, precise, sensitive and economical procedures for simultaneous determination of aceclofenac and paracetamol in tablet dosage form have been developed. In the present investigation, mixture of 20 mL (2 M) urea, 30 mL of (5 M) sodium acetate (hydrotropic solubilizing agent) was used to solubilize aceclofenac and paracetamol and carried out spectrophotometric analysis. The methods employed were absorbance ratio method (method I), derivative method (method II).The result showed that Beer’s law was obeyed in concentration range of 5-50 μg/mL with good linearity (r2?0.99) for both the drugs in both methods. The recoveries were within 99.67-101.33% for aceclofenac and 99.46-101.92% for paracetamol. Precision was good with acceptable limits of detection (LOD) and quantitation (LOQ) for both compounds. The optimized methods showed good reproducibility and recovery with standard deviation of < 1.0% and percent relative standard deviation less than 2.0%.
Absorbance ratio method, Derivative method, Acelofenac, Paracetamol, Mixed hydrotropy