Pyrazolines are prominent nitrogen-containing heterocyclic compounds and therefore, various procedures have been worked out for their synthesis. Pyrazolines have variety of methods for their synthesis but one of the popular methods is of Fischer and Knoevenagel i.e<. the reaction of α, β-unsaturated ketones with phenyl hydrazine in acetic acid under refluxing condition. However depending on the reactivity of molecules and need of the chemist, they had synthesized the pyrazolines under different solvent media and acidic or basic conditions.
Pyrazolines, Claisen-Schmidt condensation, Chalcones, Biological activity