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  • Chem Sci Trans., 2014, 3(3),  pp 861-875  

    DOI:10.7598/cst2014.796

    Review Article

    Review on Synthesis of Bioactive Pyrazoline Derivatives

  • S.SHARMA1*, SANDEEP KAUR2, TANIA BANSAL3 and JYOTI GABA3
  • 1Department of Plant Breeding & Genetics, Punjab Agricultural University, Ludhiana-141004, India
    2Department of Soil Science, Punjab Agricultural University, Ludhiana-141004, India
    3Department of Chemistry, Punjab Agricultural University, Ludhiana-141004, India
  • Abstract

    Pyrazolines are prominent nitrogen-containing heterocyclic compounds and therefore, various procedures have been worked out for their synthesis. Pyrazolines have variety of methods for their synthesis but one of the popular methods is of Fischer and Knoevenagel i.e<. the reaction of α, β-unsaturated ketones with phenyl hydrazine in acetic acid under refluxing condition. However depending on the reactivity of molecules and need of the chemist, they had synthesized the pyrazolines under different solvent media and acidic or basic conditions.

    Keywords

    Pyrazolines, Claisen-Schmidt condensation, Chalcones, Biological activity

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