• image 01
    Volume 1, No.1, 2012
  • image 02
    Volume 1, No.2, 2012
  • image 01
    Volume 1, No.3, 2012
  • image 02
    Volume 2, No.1, 2013
  • image 02
    Volume 2, No.2, 2013
  • image 02
    Volume 2, No.S1, 2013
  • image 02
    Volume 2, No.3, 2013
  • image 02
    Volume 2, No.4, 2013
  • image 02
    Volume 3, No.1, 2014
  • image 02
    Volume 3, No.2, 2014
  • Volume 3, No3
    Volume 3, No.3, 2014
  • Volume 3, No4
    Volume 3, No.4, 2014
  • Volume 4, No1
    Volume 4, No.1, 2015
  • Volume 4, No2
    Volume 4, No.2, 2015
  • Volume 4, No3
    Volume 4, No.3, 2015
  • Volume 4, No4
    Volume 4, No.4, 2015
  • Volume 5, No1
    Volume 5, No.1, 2016
  • image 01
  • image 02
  • Login|Register
  • Chem Sci Trans., 2014, 3(3),  pp 1094-1098  

    DOI:10.7598/cst2014.817

    Research Article

    Synthesis and Antimicrobial Evaluation of Novel Azetidinones

  • SANJAY D. PRAJAPATI and M. K. THAKUR*
  • Department of Chemistry, Municipal Arts and Urban Science College, Mehsana-384002 (Guj.), India
  • Abstract

    3-(4-Aminophenylsulfonyl)-1,3,4-oxadiazole-2(3H<)-thione (1) undergoes facile condensation with different aromatic aldehydes to afford the corresponding 3-(4-(substituted benzylideneamino)phenylsulfonyl)-1,3,4-oxadiazole-2(3H)-thione (2a-e) in good yields. Cyclocondensation of compounds (2a-e) with chloroacetyl chloride yields 3-chloro-4- subsituted phenyl-1-(4-(2-thioxo-1,3,4-oxadiazol-3(2H)-ylsulfonyl)phenyl)azetidin-2-one (3a-e). The structures of these compounds were established on the basis of analytical and spectral data. All the newly synthesized compounds were evaluated for their antibacterial and antifungal activities

    Keywords

    3-(4-Aminophenylsulfonyl)-1,3,4-oxadiazole-2(3H)-thione, Schiff base, Azetidinone, Antibacterial activity.

    This article has been viwed 2000 times

      

    Citations for this article 0

      

    No Citations