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  • Chem Sci Trans., 2014, 3(2),  pp 791-795  

    DOI:10.7598/cst2014.820

    Research Article

    Antioxidant Potential of Aegle marmelos Leaves Against Aflatoxin B1 Induced Liver Toxicity in Rats

  • D. SIVANESAN and V. HAZEENA BEGUM
  • Unit of Biochemistry, Department of Siddha Medicine, Faculty of Sciences, Tamil University, Thanjavur - 613 005, Tamilnadu, India
  • Abstract

    Aegle marmelos leaves have been used for treatment of various liver aliments from time immemorial. Pre-treatment of A.marmelos leaves crude powder at its therapeutic dose (1 kg/kg body weight) was carried out to determine the efficacy on aflatoxin B1 (AFB1) (100 g/kg body weight) induced liver toxicity in rats. The crude powder of A.marmelos was found to be a potent inducer of the phase II detoxifying enzyme GST and promotes the antioxidant activity by controlling lipid peroxidation in the liver of AFB1 toxicated male albino (Wistar) rats.

    Keywords

    Aflatoxin B1, Aegle marmelos, Detoxification, Antioxidants

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