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  • Chem Sci Trans., 2014, 3(2),  pp 840-846  

    DOI:10.7598/cst2014.828

    Research Article

    Analytical Techniques for the Determination of Erlotinib HCl in Pharmaceutical Dosage Forms by Spectrophotometry

  • M. MATHRUSRI ANNAPURNA, B. VENKATESH and R. KRISHNA CHAITANYA
  • Department of Pharmaceutical Analysis & Quality Assurance, GITAM Institute of Pharmacy, GITAM University, Visakhapatnam, India
  • Abstract

    Three simple, rapid and sensitive spectrophotometric methods were developed for the determination of Erlotinib hydrochloride in pharmaceutical formulations. Beer’s law was obeyed over a concentration range 0.5-30 µg/mL in HCl and acetate buffer and 1-30 µg/mL in phosphate buffer. The linear regression equations were found to be y = 0.0717x + 0.0083, y = 0.0676x + 0.0102 and y = 0.0638x + 0.0096 in HCl, acetate buffer and phosphate buffer respectively and the three methods were validated as per ICH guidelines.

    Keywords

    Erlotinib HCl, Spectrophotometry, Validation

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