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  • Chem Sci Trans., 2014, 3(2),  pp 602-607  

    DOI:10.7598/cst2014.831

    Research Article

    A Validated Liquid Chromatographic Method for the Determination of Solifenacin Succinate (Urinary Antispasmodic) in Tablets

  • M. MATHRUSRI ANNAPURNA, G. SOWJANYA, M. SANTOSH NAIDU and D. LOHITHASU
  • GITAM Institute of Pharmacy, GITAM University, Visakhapatnam, India
  • Abstract

    An isocratic reversed-phase liquid chromatographic method was developed and validated for the determination of Solifenacin succinate. Chromatographic separation was achieved on a C18 column using an aqueous tetra butyl ammonium hydrogen sulphate (10 mM): acetonitrile (40:60, v/v), with flow rate
    0.8 mL/min (UV detection at 254 nm). Linearity was observed in the concentration range of 20-200 µg/mL (R2= 0.999). The limit of quantitation was found to be 0.845 µg/mL and the limit of detection was found to be 0.0269 µg/mL. The method was validated as per ICH guidelines. The method is simple, precise, robust and accurate for the determination of Solifenacin in tablet dosage forms.

    Keywords

    RP-HPLC, Solifenacin succinate, Validation, Tablets

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