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  • Chem Sci Trans., 2014, 3(3),  pp 1147-1155  

    DOI:10.7598/cst2014.847

    Research Article

    Facile Synthesis and Antimicrobial Activities of 5H-[1,2,4]triazol[1,3,4]thiadiazine Derivatives

  • G. S. KALWANIA*, SAVITA CHOUDHARY and S. CHOMAL
  • Department of Chemistry, S. K. Govt. P.G. College (University of Rajasthan), Sikar, India
  • Abstract

    Structurally diverse new series of 5H-[1,2,4]triazolo[3,4b] [1,3,4]thiadiazine heterocycles having medicinally privileged nucleus have been synthesized by simple and solvent free environmental benign methods. A mixture of 4-amino-5-substituted-1,2,4-triazolo-3-thiol and β-diketone/ β-ketoester and catalytic amount of hydrazine hydrate exposed to microwave irradiation in microwave oven. The intermediate 4-amino-1,2,4-triazole-3-thiols were also synthesized by entirely new solvent free environmental friendly methods. The synthesized target compounds (4a-o) were characterized by elemental analysis as well as spectral studies and screened for antimicrobial activities.

    Keywords

    1,2,4-Triazole, 1,4-Thiazine, 1,3,4-Thiadiazine, Biodynamic nucleus, β-Ketoester, Irradiation, Antimicrobial, Microwave.

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