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  • Chem Sci Trans., 2014, 3(4),  pp 1483-1487  

    DOI:10.7598/cst2014.867

    Research Article

    Synthesis and Antimicrobial Evaluation of Some Substituted-3-Aryl -2,3,4,5,6,7-hexahydro-1H-inden-1-one

  • MANJUNATH MOGER, DARSHAN RAJ C GOVINDRAJU, RAMA MOHAN HINDUPUR and HARI NARAYAN PATI*
  • Advinus Therapeutics Ltd., 21 & 22, Phase II, Peenya Industrial Area, Bangalore-560058, Karnataka, India
    Department of Bio-Medicinal Research, Vidya Herbs Pvt. Ltd., Bangalore-562106, Karnataka, India
  • Abstract

    Synthesis of new cyclopentenone derivatives by reacting 1-acetyl-1-cyclohexene with various aromatic and heteroaromatic aldehydes is reported. All the new cyclopentenone derivatives were characterized by 1H, 13C NMR, IR and mass spectral data, and were further screened for their antimicrobial activity. Most of the compounds showed comparable activities with standard drug ciprofloxacin and in particular, compounds 3d, 3f, 3g and 3j showed excellent activity against all the four bacterial strains.

    Keywords

    Cyclopentenone, Nazarov reaction, Acetic acid, Anti-microbial activity

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