• image 01
    Volume 1, No.1, 2012
  • image 02
    Volume 1, No.2, 2012
  • image 01
    Volume 1, No.3, 2012
  • image 02
    Volume 2, No.1, 2013
  • image 02
    Volume 2, No.2, 2013
  • image 02
    Volume 2, No.S1, 2013
  • image 02
    Volume 2, No.3, 2013
  • image 02
    Volume 2, No.4, 2013
  • image 02
    Volume 3, No.1, 2014
  • image 02
    Volume 3, No.2, 2014
  • Volume 3, No3
    Volume 3, No.3, 2014
  • Volume 3, No4
    Volume 3, No.4, 2014
  • Volume 4, No1
    Volume 4, No.1, 2015
  • Volume 4, No2
    Volume 4, No.2, 2015
  • Volume 4, No3
    Volume 4, No.3, 2015
  • Volume 4, No4
    Volume 4, No.4, 2015
  • Volume 5, No1
    Volume 5, No.1, 2016
  • image 01
  • image 02
  • Login|Register
  • Chem Sci Trans., 2014, 3(4),  pp 1576-1582  

    DOI:10.7598/cst2014.897

    Research Article

    Development and Validation of RP-HPLC Method for the Estimation of Voriconazole in Bulk and Pharmaceutical Dosage Form

  • SREERAMAMURTHY PYLA*, K. SRINIVAS, JOGENDRAKUMAR YVV, JAGADEESH PANDA and P. SANDHYA ROSE
  • Raghu College of Pharmacy, Dakamarri (V), Bheemili (M), Visakhapatnam Dist. A.P, India
    Sri Vasavi Institute of Pharmaceutical Sciences, T. P. Gudem, E. G District, A.P, India
  • Abstract

    A simple, accurate and precise reverse phase HPLC method was developed for the estimation of Voriconazole in bulk and pharmaceutical dosage form. The drug was resolved on an enable C18G column (250 mm x 4.6 mm i.d, 5 μm particle size) used with photodiode array UV-Visible detector using the mobile phase consisting of Acetonitrile and water in the ratio of 60:40V/V. The flow rate was 1 mL/min and the effluent was monitored at 256 nm. The retention time of the drug was 5.360 min. The linearity of the drug was found to be the concentration range 10-50 μg/mL. The method was found to be reproducible with relative standard deviation of <2%. The percentage recovery was 99.89-100.86%. The results of method have been validated according to ICH guidelines requirements. This method can be successfully employed for the quantitative analysis of Voriconazole in bulk and pharmaceutical dosage form.

    Keywords

    Voriconazole, Reverse phase HPLC, Method development, UV-Visible detector

    This article has been viwed 1496 times

      

    Citations for this article 0

      

    No Citations