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  • Chem Sci Trans., 2014, 3(4),  pp 1310-1317  

    DOI:10.7598/cst2014.904

    Research Article

    Green and Efficient Microwave Assisted Synthesis of Schiff Bases and Hydroxyl Derivatives of 1, 3, 4-Thiadiazole Containing N-Methyl Piperazine Moiety and their Antimicrobial and Antioxidant Potential

  • CHANDRA PRAKASH GHARU
  • Department of Chemistry, Government College Merta City, Nagaur, Rajasthan, India
  • Abstract

    A new class of thiadiazole having combination of Schiff base and Mannich base containing N-methyl piperazine moiety was synthesized by an efficient microwave assisted green synthetic approach. Antioxidant activity of methanolic solutions of synthesized compounds was determined by Reducing power assay and Hydrogen peroxide scavenging activity at 700 nm and 250 nm respectively. The synthesized compounds were also screened for antbacterial activity and were characterized by FTIR, 1H NMR and elemental analysis.

    Keywords

    Thiadiazole, Schiff bases, Mannich bases, N-methyl piperazine, Antimicrobial activity, Antioxidant activity

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