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  • Chem Sci Trans., 2015, 4(1),  pp 69-74  

    DOI:10.7598/cst2015.909

    Research Article

    UV Assay Method for the Determination of Doxycycline Hyclate in Bulk and Pharmaceutical Formulation

  • V. SREERAM*, A. V. D. NAGENDRAKUMAR1, SRINIVASA RAO KARUMURI2 and M. MADHU3
  • *P.G. Department of Chemistry, A.G & S.G. Siddhartha College of Arts & Science, Vuyyuru-521 165, India
    iDepartment of Chemistry, GITAM University, Visakhapatnam-530 045, Andhra Pradesh, India
    2Department of Electronics & Instrumentation, Lakireddy Bali Reddy College of Engineering, Mylavaram, A.P, India
    3Department of Chemistry, P.B. Siddhartha College of Arts & Science, Vijayawada, A.P. India
  • Abstract

    A simple, selective, linear, precise and accurate UV Assay method was developed and validated for rapid assay of Doxycycline hyclate in bulk and pharmaceutical formulation. For this development paddle apparatus were used. The purified water was used as dissolution medium and solvent. Stirring rate was employed at 75 rpm and the withdrawal time was identified as 30 minutes and the filter size was found to be 0.45 μ m at ambient temperature. The method was validated as per the ICH guidelines. The method was successfully applied for routine analysis of Doxycycline hyclate in the rapid and reliable determination in pharmaceutical formulation.

    Keywords

    Doxycycline hyclate, RP-HPLC, UV detection, Recovery

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