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  • Chem Sci Trans., 2014, 3(4),  pp 1583-1589  

    DOI:10.7598/cst2014.911

    Research Article

    Synthesis and Characterization of Some New 4,5-Dihydropyrazolyl Thiazoles

  • FAROUQ E. HAWAIZ
  • Department of Chemistry, College of Education, University of Salahaddin-Hawler, Kurdistan Region, Iraq
  • Abstract

    The prepared starting material 2,4-bis (4-chlorobenzyloxy)acetophenone (1) has been reacted with different substituted benzaldehydes to give a series of new chalcones (2a-j). The prepared new chalcones were subjected to react with thiosemicarbazide according to the Michael addition reaction to afford new thiocarbamoylpyrazoline derivatives (3a-j). A thiocarbamoyl group in compounds (3a-j) was cyclized with p-bromophenacyl bromide to give a series of new 4,5-dihydropyrazolyl thiazoles (4a-j). The structures of the synthesized compounds were characterized by spectral methods: FT-IR, 1H-NMR, 13C-NMR and DEPT-135 spectra.

    Keywords

    Chalcones, Benzylation, Pyrazoline, Thiazole, Thiosemicarbazide

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