Abstract

The prepared starting material 2,4-bis (4-chlorobenzyloxy)acetophenone (1) has been reacted with different substituted benzaldehydes to give a series of new chalcones (2a-j). The prepared new chalcones were subjected to react with thiosemicarbazide according to the Michael addition reaction to afford new thiocarbamoylpyrazoline derivatives (3a-j). A thiocarbamoyl group in compounds (3a-j) was cyclized with p-bromophenacyl bromide to give a series of new 4,5-dihydropyrazolyl thiazoles (4a-j). The structures of the synthesized compounds were characterized by spectral methods: FT-IR, ¹H-NMR, ¹³C-NMR and DEPT-135 spectra.

Keywords

Chalcones, Benzylation, Pyrazoline, Thiazole, Thiosemicarbazide