The objective of present investigation was to develop curcumin loaded cubosomes and evaluated for topical delivery. Curcumin-loaded cubosomes were prepared by homogenization method and prepared curcumin nano cubosomes were evaluated regarding microscopic studies, particle size analysis, zeta potential, entrapment efficiency (EE%). Cubosomes hydrogels were prepared by using carbopol as gelling agent and evaluated for appearance, pH, viscosity, entrapment efficiency, in vitro drug diffuse studies, skin irritation studies and anti bacterial activity. The particle size of the formulation was about 75.2 nm and zeta potential -24 mv. The developed curcumin loaded cubosomal hydrogel gave rise to stable, nano-sized vesicles, able to improve curcumin anti bacterial activity in topical drug delivery.
Curcumin, Glycerol mono oleate, Cubosome, Hydrogel, Characterization, Antibacterial activity