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  • Chem Sci Trans., 2015, 4(2),  pp 611-619  

    DOI:10.7598/cst2015.999

    Research Article

    Multicomponent Reaction, Ionic Liquid and Aqua Mediated: A Perfect Synergy for Eco-compatible Heterocyclic Synthesis

  • FAIZA BOUKEZZOULA, TAOUES BOUMOUD*, BOUDJEMAA BOUMOUD and ABDELMADJID DEBACHE
  • Laboratoire de Synthèse de Molécules d'Intérêts Biologiques, Département de Chimie, Faculté des Sciences Exactes, Université Constantine 1, 25000 Constantine, Algérie.
  • Abstract

    The combination of multicomponent reactions as potential synthetic processes with ionic liquids as catalysts and water as reaction medium is a suitable approach that respects, in some extent, the requirements of sustainable chemistry. In this context, we describe herein an efficient and high yielding four-component synthesis of 6-amino-4-alkyl/aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles involving ethyl acetoacetate, hydrazine hydrate, malononitrile, and various aldehydes using methyltriphenylphosphonium bromide as calalyst and water as solvent under mild reaction conditions.

    Keywords

    Pyranopyrazoles, Triphenylphosphine, Methyltriphenylphosphonium bromide, Ionic liquid, Aqueous medium, Multicomponent reactions, Organocatalyst, Rate enhancements

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