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  • Chem Sci Trans., 2018, 7(4),  pp 676-686  

    DOI:10.7598/cst2018.1528

    Research Article

    Silica Supported MTSA Catalyst for the Synthesis of 5-Substituted-1H-tetrazole- A Green Chemistry Approach

  • DHARMESH H. MAHAJAN*, DIPESH MISTRY and HETAL TAILOR
  • Government Science College, Fort-Songadh, Dist-Tapi, Gujarat, India
  • Abstract

    We have developed simple, cost efficient and environmentally benign protocol for the synthesis of 5-substituted 1H-tetrazole via [2+3] cyclo addition reaction from organic nitrile and sodium azide in refluxing DMF by using heterogeneous catalyst as MTSA (Melamine tri sulphonic acid). The corresponding 5-substituted 1H-tetrazole were obtained in lower yield but when using silica supported MTSA the yield obtained 85% in 6 h. After completion of the reaction, the catalyst was recovered by filtration and reused with only a slight decrease of activity observed under the same reaction conditions. Various aliphatic and aromatic nitrile converted in corresponding 5-substituted 1H-tetrazole in excellent yield without any contamination

    Keywords

    5-Substituted-1H-tetrazole, Aryl nitriles, Sodium azide, MTSA, Silica, Supported, Catalysis

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