• image 01
    Volume 1, No.1, 2012
  • image 02
    Volume 1, No.2, 2012
  • image 01
    Volume 1, No.3, 2012
  • image 02
    Volume 2, No.1, 2013
  • image 02
    Volume 2, No.2, 2013
  • image 02
    Volume 2, No.S1, 2013
  • image 02
    Volume 2, No.3, 2013
  • image 02
    Volume 2, No.4, 2013
  • image 02
    Volume 3, No.1, 2014
  • image 02
    Volume 3, No.2, 2014
  • Volume 3, No3
    Volume 3, No.3, 2014
  • Volume 3, No4
    Volume 3, No.4, 2014
  • Volume 4, No1
    Volume 4, No.1, 2015
  • Volume 4, No2
    Volume 4, No.2, 2015
  • Volume 4, No3
    Volume 4, No.3, 2015
  • Volume 4, No4
    Volume 4, No.4, 2015
  • Volume 5, No1
    Volume 5, No.1, 2016
  • image 01
  • image 02
  • Login|Register
  • Chem Sci Trans., 2019, 8(2),  pp 289-294  

    DOI:10.7598/cst2019.1602

    Research Article

    Indirect Spectrophotometric Determination of Amoxicillin by Oxidative with Cerium ammonium Nitrate Using Arsenazo III as a Reagent

  • AMEERA H. HAMED1, SURA K. IBRAHIM1, SAADIYAHA.DHAHIR1* and AMAL H. MHEMEED2
  • 1Department of Chemistry, University of Baghdad, College Science for Women, Iraq.
    2College of Pharmacy, University of Masan, Iraq
  • Abstract

    A simple, accurate and sensitive spectrophotometric way used for preparation. The suggested method depends on using arsenazo III as reagent. The current method was depending on oxidative coupling reaction of amoxicillin by cerium ammonium nitrate with arsenazo III in the presence of sulfuric acid as acidic media. Then reaction Ce(III) with arsenazo III to form pink water-soluble dye product that has a maximum absorption at max 500 nm. Beers law is obeyed in the concentration of (1-10 μgmL-1). The molar absorptivity is 3x104 L.mol-1.cm-1, a sandal sensitivity of 0.012 μgcm-2. Limit of detection (LOD) and limit of quantitation are 0.00874 μgmL-1, (LOQ) 0.0291 μgmL-1 respectively. The analytical recovery of the new method was good (100.72%). The method successfully applied for the determination of Amoxicillin in pharmaceutical preparations.

    Keywords

    Amoxicillin, Spectrophotometry, Arsenazo III

    This article has been viwed 524 times

      

    Citations for this article 0

      

    No Citations