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  • Chem Sci Trans., 2013, 2(1),  pp 129-134  

    DOI:10.7598/cst2013.338

    Research Article

    An Efficient and Environmentally Friendly Procedure for Synthesis of Quinazolinone Derivatives by Use of a Biginelli-Type Reaction

  • NADIA T. A. DAWOUD
  • Department of Chemistry, Faculty of Science “Girls”, Al-Azhar University, Nasr City, Cairo, Egypt
  • Abstract

    A Biginelli one-pot three-component reaction involving cyclohexanone, aromatic/or heterocyclic aldehyde and urea thiourea or guanidine HCl was applied in this work to prepare quinazolin-2(1H)one derivatives under solvent free and microwave irradiation assistance as well as conventional method. The major advantages of this protocol are high yields, operational simplicity, short reaction time and environment friendly. The purity of the synthesized compounds was characterized by means of IR, 1H NMR, 13C NMR, mass spectral and elemental analysis.

    Keywords

    Multi-component reactions, Microwave assisted synthesis, Quinazolin-2(1H)-one derivatives, Green chemistry

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