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Preparation, Characterization and In-Vitro Release Study of Flurbiprofen Loaded Stealth Liposomes

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1TitleTitle of DocumentPreparation, Characterization and In-Vitro Release Study of Flurbiprofen Loaded Stealth Liposomes
2CreatorAuthor's name, affiliation, country M.YASMIN BEGUM1*, K. ABBULU2 and M. SUDHAKAR3
1Department of Pharmaceutics, 1Department of Biotechnology, 3Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad-500014, India
2Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Secunderabad.-500014, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Stealth liposomes, Stability, In vitro release, FTIR, SEM analysis.
4DescriptionAbstract The objective of the study was to prepare flurbiprofen loaded stealth liposome formulations by optimizing the various process and formulation related variables. Various liposomal batches were prepared by thin film hydration technique and they were characterized for drug encapsulation %, chemical interaction of the drug and excipients, vesicle size, drug release profile in vitro and stability using specified methods. The best flurbiprofen loaded liposome was composed of DSPC/Cholesterol group of 4:1 mole ratio and the best stealth liposome was composed of DSPC/CH/ PE 18:0|18:0-PEG 2000 (PE-PEG) group of 4:1:0.2 mole ratios. Stealth liposome was found to have greater stability, higher drug encapsulation % and lower drug release in vitro compared to others. The drug encapsulation efficiency of stealth liposomes was 68% and it could retain 70.9% of the drug even after 24 h. FTIR study indicated that there is no significant chemical interaction between the components. SEM photograph confirmed that vesicles were homogenous and spherical in shape. Stability studies showed that the vesicles were stable in
-20 C and refrigerated temperature (4 C) for one month without significant differences in drug entrapment. The present study has given us knowledge also that liposomes with low amount of cholesterol are better candidate for flurbiprofen liposomes.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2012.108
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  1 , Number  (1), (2012)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
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