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A New Approach to the Synthesis of Cyanamide:
2-Cyanoimino-4-aryl-6-(naphthalen-2-yl)-3,4-dihydro-1H-pyrimidines and their Antimicrobial Screening
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| DUBLIN | CORE | METADATA ITEM | METADATA FOR THIS DOCUMENT |
| 1 | Title | Title of Document | A New Approach to the Synthesis of Cyanamide:
2-Cyanoimino-4-aryl-6-(naphthalen-2-yl)-3,4-dihydro-1H-pyrimidines and their Antimicrobial Screening
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| 2 | Creator | Author's name, affiliation, country | N.PRAKASH, M.ELAMARAN and N. INGARSAL*
P G and Research Department of Chemistry,
Rajah Serfoji Govt. College, Thanjavur-05, Tamilnadu, India
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| 3 | Subject | Dicipline(s) | Chemical Science |
| 3 | Subject | Keywords | Synthesis, Acetylnaphthalene, Chalcones, Cyanoguanidine, Cyanoiminopyrimidines |
| 4 | Description | Abstract | A series of cyanoiminopyrimidines were synthesized by the reaction of 1-(2-naphthyl)-3-arylprop-2-en-1-ones with cyanoguanidine in the presence of sodium hydroxide in ethanol. The mechanism involves the 1,4 or 1,2-addition of cyanoguanidine to α, β-unsaturated ketone, heterocyclisation and subsequent tautomeric change of formed adduct with loss of water. All the newly synthesized compounds were characterized by IR and NMR spectral studies. The in vitro antimicrobial screening of synthesized compounds showed the significant antifungal activities compared to the standard fluconazole. |
| 5 | Publishers | Organizing agency, location | WWW Publications, India |
| 6 | Contributor | Sponsor(s) | - |
| 7 | Date | Date (YYYY-MM-DD) | - |
| 8 | Type | Status & genre | Peer-reviewed Article |
| 8 | Type | Type | |
| 9 | Formate | File Formate | PDF |
| 10 | Identifier | Uniform Resource Identifier | Click Here |
| 10 | Identifier | Digital Object Identifier | |
| 11 | Source | Journal/conference title; vol., no. (Year) | Chemical Science Transactions, Volume 4 , Number (4), (2015) |
| 12 | Lanuguage | English=en | en |
| 13 | Relation | Supp.files | |
| 14 | Coverage | | - |
| 15 | Copyright | Copyright and permissions | |
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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