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A New Approach to the Synthesis of Cyanamide: 2-Cyanoimino-4-aryl-6-(naphthalen-2-yl)-3,4-dihydro-1H-pyrimidines and their Antimicrobial Screening

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1TitleTitle of DocumentA New Approach to the Synthesis of Cyanamide: 2-Cyanoimino-4-aryl-6-(naphthalen-2-yl)-3,4-dihydro-1H-pyrimidines and their Antimicrobial Screening
2CreatorAuthor's name, affiliation, country N.PRAKASH, M.ELAMARAN and N. INGARSAL*
P G and Research Department of Chemistry, Rajah Serfoji Govt. College, Thanjavur-05, Tamilnadu, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Synthesis, Acetylnaphthalene, Chalcones, Cyanoguanidine, Cyanoiminopyrimidines
4DescriptionAbstract A series of cyanoiminopyrimidines were synthesized by the reaction of 1-(2-naphthyl)-3-arylprop-2-en-1-ones with cyanoguanidine in the presence of sodium hydroxide in ethanol. The mechanism involves the 1,4 or 1,2-addition of cyanoguanidine to α, β-unsaturated ketone, heterocyclisation and subsequent tautomeric change of formed adduct with loss of water. All the newly synthesized compounds were characterized by IR and NMR spectral studies. The in vitro antimicrobial screening of synthesized compounds showed the significant antifungal activities compared to the standard fluconazole.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2015.1091
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  4 , Number  (4), (2015)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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