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Synthesis, Characterisation, Antimicrobial Evaluation of Chalcones and its Cyclised Product: Phenyl Pyrazolines and Benzodiazepines |
DUBLIN | CORE | METADATA ITEM | METADATA FOR THIS DOCUMENT |
1 | Title | Title of Document | Synthesis, Characterisation, Antimicrobial Evaluation of Chalcones and its Cyclised Product: Phenyl Pyrazolines and Benzodiazepines |
2 | Creator | Author's name, affiliation, country | ANJANI SOLANKEE* and RIKI TAILOR Department of Chemistry, B. K. M. Science College, Valsad-396001
(Affiliated to the Veer Narmad South Gujarat University, Surat) India
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3 | Subject | Dicipline(s) | Chemical Science |
3 | Subject | Keywords | Chalcones, Phenyl pyrazolines, Benzodiazepines, Claisen-Schmidt reaction, Antimicrobial activity |
4 | Description | Abstract | A conventional root was designed and synthesised for the pyrazolines and benzodiazepines from chalcones. The synthesis of chalcones (7j-n) was accomplished according to the Claisen-Schmidt condensation of substituted acetophenones (C) with various aldehydes. Treatment of this chalcones with phenyl hydrazine hydrochloride / alkali and o-phenylenediamine / glacial acetic acid afforded the corresponding 2- phenyl pyrazoline (8j-n) and 1,5- benzodiazepine (9j-n) derivatives respectively. The structures of all the newly synthesised compounds were established based on IR, 1H NMR, mass spectral data as well as elemental analysis. In vitro antimicrobial proficiency of the title compounds were assessed against selected pathogens. Compounds 7j, 7m, 7n, 8k, 8m and 9m exhibited excellent antimicrobial activity and said to be the most proficient members of the series compared to standard drugs |
5 | Publishers | Organizing agency, location | WWW Publications, India |
6 | Contributor | Sponsor(s) | - |
7 | Date | Date (YYYY-MM-DD) | - |
8 | Type | Status & genre | Peer-reviewed Article |
8 | Type | Type | |
9 | Formate | File Formate | PDF |
10 | Identifier | Uniform Resource Identifier | Click Here |
10 | Identifier | Digital Object Identifier | |
11 | Source | Journal/conference title; vol., no. (Year) | Chemical Science Transactions, Volume 4 , Number (4), (2015) |
12 | Lanuguage | English=en | en |
13 | Relation | Supp.files | |
14 | Coverage | | - |
15 | Copyright | Copyright and permissions | |
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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