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Synthesis, Characterisation, Antimicrobial Evaluation of Chalcones and its Cyclised Product: Phenyl Pyrazolines and Benzodiazepines

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1TitleTitle of DocumentSynthesis, Characterisation, Antimicrobial Evaluation of Chalcones and its Cyclised Product: Phenyl Pyrazolines and Benzodiazepines
2CreatorAuthor's name, affiliation, country ANJANI SOLANKEE* and RIKI TAILOR
Department of Chemistry, B. K. M. Science College, Valsad-396001 (Affiliated to the Veer Narmad South Gujarat University, Surat) India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Chalcones, Phenyl pyrazolines, Benzodiazepines, Claisen-Schmidt reaction, Antimicrobial activity
4DescriptionAbstract A conventional root was designed and synthesised for the pyrazolines and benzodiazepines from chalcones. The synthesis of chalcones (7j-n) was accomplished according to the Claisen-Schmidt condensation of substituted acetophenones (C) with various aldehydes. Treatment of this chalcones with phenyl hydrazine hydrochloride / alkali and o-phenylenediamine / glacial acetic acid afforded the corresponding 2- phenyl pyrazoline (8j-n) and 1,5- benzodiazepine (9j-n) derivatives respectively. The structures of all the newly synthesised compounds were established based on IR, 1H NMR, mass spectral data as well as elemental analysis. In vitro antimicrobial proficiency of the title compounds were assessed against selected pathogens. Compounds 7j, 7m, 7n, 8k, 8m and 9m exhibited excellent antimicrobial activity and said to be the most proficient members of the series compared to standard drugs
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  4 , Number  (4), (2015)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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