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Synthesis, Cytotoxic Activity and Molecular Docking Studies of 4-Aryl-6-methyl-3,4-Dihydropyrimidin-2(1H)-ones/thiones with Eg5 Protein |
| DUBLIN | CORE | METADATA ITEM | METADATA FOR THIS DOCUMENT |
| 1 | Title | Title of Document | Synthesis, Cytotoxic Activity and Molecular Docking Studies of 4-Aryl-6-methyl-3,4-Dihydropyrimidin-2(1H)-ones/thiones with Eg5 Protein |
| 2 | Creator | Author's name, affiliation, country | DURGA PRASAD BEDA* and GIRIJA SASTRY VEDULA
Department of Pharmaceutical Chemistry, AU College of Pharmaceutical Sciences, Andhra University, Vishakhapatnam, Andhra Pradesh-530003, India |
| 3 | Subject | Dicipline(s) | Chemical Science |
| 3 | Subject | Keywords | Pyrimidine, Cytotoxic activity, Docking studies |
| 4 | Description | Abstract | Various Biginelli compounds (dihydropyrimidinones, DHPM) have been synthesized efficiently and in high yields under mild, solvent free and eco-friendly conditions in a one pot reaction of 1, 3-dicarbonyl compounds, aldehydes and urea/thiourea using sodium dodecyl sulphate (SDS) as a novel catalyst under two experimental conditions have been introduced. Synthesized compounds were evaluated for their cytotoxicity screening in lung cancer (A-549) and colon cancer (HT-29) cell lines by the MTT assay method. Molecular docking studies were carried out synthesized DHPM derivatives using GOLD software with the crystal structure of Eg5 protein (1QOB) to gain some structural insights on the binding mode and possible interaction with the active site. |
| 5 | Publishers | Organizing agency, location | WWW Publications, India |
| 6 | Contributor | Sponsor(s) | - |
| 7 | Date | Date (YYYY-MM-DD) | - |
| 8 | Type | Status & genre | Peer-reviewed Article |
| 8 | Type | Type | |
| 9 | Formate | File Formate | PDF |
| 10 | Identifier | Uniform Resource Identifier | Click Here |
| 10 | Identifier | Digital Object Identifier | |
| 11 | Source | Journal/conference title; vol., no. (Year) | Chemical Science Transactions, Volume 4 , Number (4), (2015) |
| 12 | Lanuguage | English=en | en |
| 13 | Relation | Supp.files | |
| 14 | Coverage | | - |
| 15 | Copyright | Copyright and permissions | |
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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