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Synthesis, Cytotoxic Activity and Molecular Docking Studies of 4-Aryl-6-methyl-3,4-Dihydropyrimidin-2(1H)-ones/thiones with Eg5 Protein

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1TitleTitle of DocumentSynthesis, Cytotoxic Activity and Molecular Docking Studies of 4-Aryl-6-methyl-3,4-Dihydropyrimidin-2(1H)-ones/thiones with Eg5 Protein
2CreatorAuthor's name, affiliation, country DURGA PRASAD BEDA* and GIRIJA SASTRY VEDULA
Department of Pharmaceutical Chemistry, AU College of Pharmaceutical Sciences, Andhra University, Vishakhapatnam, Andhra Pradesh-530003, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Pyrimidine, Cytotoxic activity, Docking studies
4DescriptionAbstract Various Biginelli compounds (dihydropyrimidinones, DHPM) have been synthesized efficiently and in high yields under mild, solvent free and eco-friendly conditions in a one pot reaction of 1, 3-dicarbonyl compounds, aldehydes and urea/thiourea using sodium dodecyl sulphate (SDS) as a novel catalyst under two experimental conditions have been introduced. Synthesized compounds were evaluated for their cytotoxicity screening in lung cancer (A-549) and colon cancer (HT-29) cell lines by the MTT assay method. Molecular docking studies were carried out synthesized DHPM derivatives using GOLD software with the crystal structure of Eg5 protein (1QOB) to gain some structural insights on the binding mode and possible interaction with the active site.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2015.1116
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  4 , Number  (4), (2015)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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