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Synthesis of New Pyrazole Derivatives Containing Quinoline Moiety via Chalcones: A Novel Class of Potential Antibacterial and Antifungal Agents

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1TitleTitle of DocumentSynthesis of New Pyrazole Derivatives Containing Quinoline Moiety via Chalcones: A Novel Class of Potential Antibacterial and Antifungal Agents
2CreatorAuthor's name, affiliation, country G. MANJUNATH, M. MAHESH, G. BHEEMARAJU and P. VENKATA RAMANA*
Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu-515003, Andhra Pradesh, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Quinolin-8-ol, Ethyl chloroacetate, Hydrazine hydrate, Chalcone, Pyrazole, Antibacterial activity and Antifungal activity
4DescriptionAbstract In the present investigation a new class of quinoline derivatives containing pyrazole moiety have been designed and synthesized by condensation of 2-(quinolin-8-yloxy)acetohydrazide with various chalcones. These newly synthesized quinoline derivatives containing pyrazole moiety were screened for their minimum inhibitory concentration by antibacterial activity against two kinds of strains i.e. Staphylococcus aureus, Escherichia coli and antifungal activity against Aspergillus niger. The results showed that some of the compounds exhibited moderate to good antibacterial activity against both the strains and a few compounds were active in antifungal activity. The structure?activity relationships were briefly discussed. The studies indicated that variation of substituent in the aromatic rings changes the antibacterial activity and compounds containing electron withdrawing groups exhibited potential antifungal activity
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2016.1140
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  5 , Number  (1), (2016)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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