| DUBLIN | CORE | METADATA ITEM | METADATA FOR THIS DOCUMENT |
| 1 | Title | Title of Document | Synthesis of New Pyrazole Derivatives Containing Quinoline Moiety via Chalcones: A Novel Class of Potential Antibacterial and Antifungal Agents |
| 2 | Creator | Author's name, affiliation, country | G. MANJUNATH, M. MAHESH, G. BHEEMARAJU and P. VENKATA RAMANA*
Department of Chemistry, Sri Krishnadevaraya University,
Ananthapuramu-515003, Andhra Pradesh, India
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| 3 | Subject | Dicipline(s) | Chemical Science |
| 3 | Subject | Keywords | Quinolin-8-ol, Ethyl chloroacetate, Hydrazine hydrate, Chalcone, Pyrazole, Antibacterial activity and Antifungal activity |
| 4 | Description | Abstract | In the present investigation a new class of quinoline derivatives containing pyrazole moiety have been designed and synthesized by condensation of 2-(quinolin-8-yloxy)acetohydrazide with various chalcones. These newly synthesized quinoline derivatives containing pyrazole moiety were screened for their minimum inhibitory concentration by antibacterial activity against two kinds of strains i.e. Staphylococcus aureus, Escherichia coli and antifungal activity against Aspergillus niger. The results showed that some of the compounds exhibited moderate to good antibacterial activity against both the strains and a few compounds were active in antifungal activity. The structure?activity relationships were briefly discussed. The studies indicated that variation of substituent in the aromatic rings changes the antibacterial activity and compounds containing electron withdrawing groups exhibited potential antifungal activity |
| 5 | Publishers | Organizing agency, location | WWW Publications, India |
| 6 | Contributor | Sponsor(s) | - |
| 7 | Date | Date (YYYY-MM-DD) | - |
| 8 | Type | Status & genre | Peer-reviewed Article |
| 8 | Type | Type | |
| 9 | Formate | File Formate | PDF |
| 10 | Identifier | Uniform Resource Identifier | Click Here |
| 10 | Identifier | Digital Object Identifier | |
| 11 | Source | Journal/conference title; vol., no. (Year) | Chemical Science Transactions, Volume 5 , Number (1), (2016) |
| 12 | Lanuguage | English=en | en |
| 13 | Relation | Supp.files | |
| 14 | Coverage | | - |
| 15 | Copyright | Copyright and permissions | |
