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Synthesis and Characterization of Impurities of an Broad- Spectrum Anthelmintic Drug, Albendazole

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1TitleTitle of DocumentSynthesis and Characterization of Impurities of an Broad- Spectrum Anthelmintic Drug, Albendazole
2CreatorAuthor's name, affiliation, country SABRINTAJ KALAS, SURYAKANT PATIL* and VIDYADHAR JADHAV
Prof. Dr. S. C. Bhattacharya Organic Synthesis Laboratory, VerGo Pharma Research Lab. Pvt. Ltd., Plot B5, Phase 1A, Verna Industrial Estate, Verna, Salcette, Goa-403 722, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Albendazole, Impurities, Synthesis, Characterization
4DescriptionAbstract Albendazole (1) is a broad-spectrum anthelmintics drug. Albendazole impurity A, 5-(propylthio)-1H-benzimidazol-2-amine (6), impurity B, methyl [5-(propylsulfinyl)- 1H-benzimidazol-2-yl]carbamate (7), impurity C, methyl [5-(propylsulfonyl)-1H- benzimidazol-2-yl]carbamate (8) and impurity D, 5-(propylsulfonyl)-1H- benzimidazol-2-amine (9) are degradation or metabolic impurities whereas impurity E, methyl 1H-benzoimidazol- 2-yl)carbamate (11) and impurity F, methyl [5-(methylthio)-1H- benzimidazol-2-yl]carbamate (15) are process related impurities. All these impurities are listed in European pharmacopoeia. Present work describes the synthesis and characterization of all these six impurities
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2016.1146
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  5 , Number  (1), (2016)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
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