Indexing Metadata
Mild and Efficient Condition for Synthesis of Gabapentin Impurity B and E |
| DUBLIN | CORE | METADATA ITEM | METADATA FOR THIS DOCUMENT |
| 1 | Title | Title of Document | Mild and Efficient Condition for Synthesis of Gabapentin Impurity B and E |
| 2 | Creator | Author's name, affiliation, country | DIPAK VARAL, DEEPAK PANMAND* and VIDYADHAR JADHAV
Prof. Dr. S. C. Bhattacharya Organic Synthesis Laboratory, VerGo Pharma Research Lab. Pvt. Ltd., Plot B5, Phase 1A, Verna Industrial Estate, Verna, Salcette, Goa-403722, India |
| 3 | Subject | Dicipline(s) | Chemical Science |
| 3 | Subject | Keywords | Gabapentin, Anticonvulsant, Impurity, Synthesis, Characterization |
| 4 | Description | Abstract | Gabapentin (1), a widely prescribed anticonvulsant used to treat epilepsy and neuropathic pain. This work describes the synthesis of two potential Gabapentin impurities as per USP and EP. Gabapentin impurity B; 2-(1-cyanocyclohexyl) acetic acid (2) was synthesized by oxidative dehydrogenation of Gabapentin API using trichloroisocyanuric acid. Impurity E; 1-(carboxymethyl) cyclohexanecarboxylic acid (3) was obtained by acid hydrolysis of 2. These impurities are characterized by IR, mass spectral data, HPLC RRT and 1H NMR |
| 5 | Publishers | Organizing agency, location | WWW Publications, India |
| 6 | Contributor | Sponsor(s) | - |
| 7 | Date | Date (YYYY-MM-DD) | - |
| 8 | Type | Status & genre | Peer-reviewed Article |
| 8 | Type | Type | |
| 9 | Formate | File Formate | PDF |
| 10 | Identifier | Uniform Resource Identifier | Click Here |
| 10 | Identifier | Digital Object Identifier | |
| 11 | Source | Journal/conference title; vol., no. (Year) | Chemical Science Transactions, Volume 5 , Number (2), (2016) |
| 12 | Lanuguage | English=en | en |
| 13 | Relation | Supp.files | |
| 14 | Coverage | | - |
| 15 | Copyright | Copyright and permissions | |
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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