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Mild and Efficient Condition for Synthesis of Gabapentin Impurity B and E

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1TitleTitle of DocumentMild and Efficient Condition for Synthesis of Gabapentin Impurity B and E
2CreatorAuthor's name, affiliation, country DIPAK VARAL, DEEPAK PANMAND* and VIDYADHAR JADHAV
Prof. Dr. S. C. Bhattacharya Organic Synthesis Laboratory, VerGo Pharma Research Lab. Pvt. Ltd., Plot B5, Phase 1A, Verna Industrial Estate, Verna, Salcette, Goa-403722, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Gabapentin, Anticonvulsant, Impurity, Synthesis, Characterization
4DescriptionAbstract Gabapentin (1), a widely prescribed anticonvulsant used to treat epilepsy and neuropathic pain. This work describes the synthesis of two potential Gabapentin impurities as per USP and EP. Gabapentin impurity B; 2-(1-cyanocyclohexyl) acetic acid (2) was synthesized by oxidative dehydrogenation of Gabapentin API using trichloroisocyanuric acid. Impurity E; 1-(carboxymethyl) cyclohexanecarboxylic acid (3) was obtained by acid hydrolysis of 2. These impurities are characterized by IR, mass spectral data, HPLC RRT and 1H NMR
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2016.1198
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  5 , Number  (2), (2016)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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