Indexing Metadata
Synthesis of Novel 5-Phenylselenenyl-2,4-Disubstituted Pyrimidine Analogs |
| DUBLIN | CORE | METADATA ITEM | METADATA FOR THIS DOCUMENT |
| 1 | Title | Title of Document | Synthesis of Novel 5-Phenylselenenyl-2,4-Disubstituted Pyrimidine Analogs |
| 2 | Creator | Author's name, affiliation, country | ISMAIL, UPENDAR REDDY CH and THALARI GANGADHAR*
Department of Chemistry, Nizam College, Bhasheerbhagh, Hyderabad-500001,
Andhra Pradesh, India |
| 3 | Subject | Dicipline(s) | Chemical Science |
| 3 | Subject | Keywords | Pyrimidine analogs, 2-Alkyllthiouracils, 5-Phenylselenenylpyrimidines,
2,4,5-Trisubstituted pyrimidines |
| 4 | Description | Abstract | 5-Phenylselenenyl-2,4-disubstituted pyrimidine analogs were prepared efficiently in four steps. Thiol group of 2-thiouracil was protected with various alkylating agents in presence of base furnishes 2-alkylthiouracils (2a-c), these on reaction with phenylselenenyl chloride in pyridine under anhydrous conditions yielded 5-phenylselenenyl-2-alkylthiouracils (3a-c). Chlorination of 5-phenyl-selenenyl-2-alkylthiouracils with excess POCl3 under reflux furnishes 5-phenylselenenyl-4-chloro-2-alkylthiopyrimidines (4a-c). Aromatic nucleophilic substitution reaction of 5-phenyl-selenenyl-4-chloro-2-alkylthiopyrimidines with oxygen nucleophiles like sodium phenoxides furnished the target compounds (5a-o) in 60-75% yield. All the synthesized compounds were evaluated for antimicrobial activities. |
| 5 | Publishers | Organizing agency, location | WWW Publications, India |
| 6 | Contributor | Sponsor(s) | - |
| 7 | Date | Date (YYYY-MM-DD) | - |
| 8 | Type | Status & genre | Peer-reviewed Article |
| 8 | Type | Type | |
| 9 | Formate | File Formate | PDF |
| 10 | Identifier | Uniform Resource Identifier | Click Here |
| 10 | Identifier | Digital Object Identifier | |
| 11 | Source | Journal/conference title; vol., no. (Year) | Chemical Science Transactions, Volume 1 , Number (1), (2012) |
| 12 | Lanuguage | English=en | en |
| 13 | Relation | Supp.files | |
| 14 | Coverage | | - |
| 15 | Copyright | Copyright and permissions | |
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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