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Synthesis of Novel 5-Phenylselenenyl-2,4-Disubstituted Pyrimidine Analogs

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1TitleTitle of DocumentSynthesis of Novel 5-Phenylselenenyl-2,4-Disubstituted Pyrimidine Analogs
2CreatorAuthor's name, affiliation, country ISMAIL, UPENDAR REDDY CH and THALARI GANGADHAR*
Department of Chemistry, Nizam College, Bhasheerbhagh, Hyderabad-500001, Andhra Pradesh, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Pyrimidine analogs, 2-Alkyllthiouracils, 5-Phenylselenenylpyrimidines,
2,4,5-Trisubstituted pyrimidines
4DescriptionAbstract 5-Phenylselenenyl-2,4-disubstituted pyrimidine analogs were prepared efficiently in four steps. Thiol group of 2-thiouracil was protected with various alkylating agents in presence of base furnishes 2-alkylthiouracils (2a-c), these on reaction with phenylselenenyl chloride in pyridine under anhydrous conditions yielded 5-phenylselenenyl-2-alkylthiouracils (3a-c). Chlorination of 5-phenyl-selenenyl-2-alkylthiouracils with excess POCl3 under reflux furnishes 5-phenylselenenyl-4-chloro-2-alkylthiopyrimidines (4a-c). Aromatic nucleophilic substitution reaction of 5-phenyl-selenenyl-4-chloro-2-alkylthiopyrimidines with oxygen nucleophiles like sodium phenoxides furnished the target compounds (5a-o) in 60-75% yield. All the synthesized compounds were evaluated for antimicrobial activities.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2012.127
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  1 , Number  (1), (2012)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
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