Indexing Metadata
Spectrophotometric Quantitative Determination of Bromhexine Hydrochloride in Bulk and Pharmaceutical Dosage Form using PDEAB Reagent |
| DUBLIN | CORE | METADATA ITEM | METADATA FOR THIS DOCUMENT |
| 1 | Title | Title of Document | Spectrophotometric Quantitative Determination of Bromhexine Hydrochloride in Bulk and Pharmaceutical Dosage Form using PDEAB Reagent |
| 2 | Creator | Author's name, affiliation, country | K.SIDDAPPA* and PRASHANT C. HANAMSHETTY
Department of Studies and Research in Chemistry, Gulbarga University,
Gulbarga -585106, Karnataka, India
|
| 3 | Subject | Dicipline(s) | Chemical Science |
| 3 | Subject | Keywords | Bromhexine, PDEAB, Spectrophotometry, Mucolytic agent, Schiff base, Validation |
| 4 | Description | Abstract | An efficient, sensitive spectrophotometric method has been developed and validated for the determination of bromhexine hydrochloride (BRH), in bulk drug and its pharmaceutical formulations. The method is based on the formation of Schiff Base with paradiethylamminobenzaldehyde (PDEAB) the reaction of drug with reagent gives a bright yellow colour. The so formed coloured species absorbance was measured at its absorption maximum (κmax) 425 nm. The Beer?s law has been obeyed in the concentration range 2-20 μ g/mL. The optical parameters were calculated as 2.42918x104 L/mol/cm, 0.016985 μ g/cm2, molar absorptivity and Sandell?s sensitivity respectively. The LOD and LOQ of the proposed method were calculated 0.2011 μ g/mL, 0.6696 μ g/mL respectively. All the variables were studied to optimize the reaction conditions. No interference was observed in the presence of common pharmaceutical excipients. The validity of the method was tested by analyzing BRH in its pharmaceutical formulations and critically tested for its accuracy by statistical tests. Good recoveries were obtained by the developed method; the obtained results were critically analyzed and successfully employed for the determination of BRH in its pharmaceutical dosage forms. |
| 5 | Publishers | Organizing agency, location | WWW Publications, India |
| 6 | Contributor | Sponsor(s) | - |
| 7 | Date | Date (YYYY-MM-DD) | - |
| 8 | Type | Status & genre | Peer-reviewed Article |
| 8 | Type | Type | |
| 9 | Formate | File Formate | PDF |
| 10 | Identifier | Uniform Resource Identifier | Click Here |
| 10 | Identifier | Digital Object Identifier | |
| 11 | Source | Journal/conference title; vol., no. (Year) | Chemical Science Transactions, Volume 5 , Number (3), (2016) |
| 12 | Lanuguage | English=en | en |
| 13 | Relation | Supp.files | |
| 14 | Coverage | | - |
| 15 | Copyright | Copyright and permissions | |
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
|
