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Electrochemical Studies of Meropenem at Glassy Carbon Electrode and its Direct Determination in Human Plasma by Square Wave Anodic Adsorptive Stripping Voltammetry

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1TitleTitle of DocumentElectrochemical Studies of Meropenem at Glassy Carbon Electrode and its Direct Determination in Human Plasma by Square Wave Anodic Adsorptive Stripping Voltammetry
2CreatorAuthor's name, affiliation, country KRISHNA KUMAR JHANKAL and D. K. SHARMA*
Electrochemical Research Laboratory, Department of Chemistry, University of Rajasthan, Jaipur (Rajasthan) -302004, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Meropenem, Square Wave Anodic Adsorptive Stripping Voltammetry, Glassy Carbon Electrode, Antibacterial
4DescriptionAbstract In present study a sensitive and fast square wave anodic adsorptive stripping voltammetric method was developed for the trace analysis of antibacterial drug meropenem in human plasma at glassy carbon electrode. The oxidation of meropenem gave a well-defined peak in Britton Robinson buffer at glassy carbon electrode. The process was diffusion controlled. A linear response was obtained between 1.0x10-7 to 4.0x10-5 M in aqueous media. The recovery studies were also achieved to check sensitivity and accuracy of the method. The proposed method was applied for the determination of meropenem in body fluids without any time-consuming extraction, separation, adsorption steps. The value of limit of detection (LOD) for human urine and human serum samples was found to be 2.27x10-6 M and 1.67x10-6 M respectively.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  5 , Number  (4), (2016)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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