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Toxicological Findings in Two Fatal Cases of Ingestion of Valproic Acid

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1TitleTitle of DocumentToxicological Findings in Two Fatal Cases of Ingestion of Valproic Acid
2CreatorAuthor's name, affiliation, country SANTOSH R. KOTE*, MANOJ R. BHANDARKAR and NITIN L. CHUTKE
Department of Toxicology, Regional Forensic Science Laboratory, Home Department, State of Maharashtra, Dhantoli, Nagpur - 440012. India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Valproic acid, Viscera, Fatal cases, Gas chromatography, Forensic toxicology
4DescriptionAbstract The case history and toxicological findings of two fatal cases of valproic acid are presented. Valproic acid extracted from visceral organs (Viscera I - Stomach, Intestine and its contents and Viscera II - pieces of Heart, Lung, Liver, Kidney and Spleen) was qualitatively determined by thin layer chromatography, chemical test and Gas chromatography, while quantitative analysis was done by gas chromatography. The qualitative results obtained from different analytical techniques were in good agreement. Quantitative determination by gas chromatography (GC) yielded the high concentration of valproic acid in Viscera I and Viscera II samples. In Case 1, toxicological analysis by GC yielded valproic acid concentration 131.17 mg in Viscera I and 67.78 mg in Viscera II per 100 g, whereas in Case 2, Viscera I and Viscera II showed 69.29 mg and 4.87 mg per 100 g Valproic acid concentration respectively. The present finding far exceeds those associated with valproate therapy and similar to the limited valproate disposition data reported in prior fatal overdoses.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2016.1304
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  5 , Number  (4), (2016)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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