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Regioselective Synthesis of Spiro-2-aminopyrimidinone Derivatives in Ionic Liquid as Green Solvent

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1TitleTitle of DocumentRegioselective Synthesis of Spiro-2-aminopyrimidinone Derivatives in Ionic Liquid as Green Solvent
2CreatorAuthor's name, affiliation, country U. S. SISODIA, S. KHOTHARI and S. AMETA
Pacific University, Udaipur, Rajasthan-313024, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Regioselectivity, Spiro-2-aminopyrimidinones-5-carbonitrile, Ionic liquid, Green solvent
4DescriptionAbstract An interesting regioselectivity was investigated for the synthesis of spiro-2-aminopyrimidinones-5-carbonitrile (4a-e) by the multicomponent condensation of cyclic ketones (1a-d) , alkyl cyanoacetates (2) and various guanidine salts (3) using 3-butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate ([BMIM][BF4]) as ionic liquid. Existence of two possible potentially active centers i.e. -CN and ?COOR groups in the intermediate to Michael adduct results in possibility of formation of two region-isomeric products i.e. spiro-2-aminopyrimidinones-5-carbonitrile (4a-e) or spiro-2-amino-4-imino-pyrimidin-5-carboxylic acid alkyl ester (5). High regioselectivity was displayed with exclusive formation of compound (4a-e) which was further confirmed by spectral studies
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2017.1316
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  6 , Number  (1), (2017)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
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