DUBLIN | CORE | METADATA ITEM | METADATA FOR THIS DOCUMENT |
1 | Title | Title of Document | Regioselective Synthesis of Spiro-2-aminopyrimidinone Derivatives in Ionic Liquid as Green Solvent |
2 | Creator | Author's name, affiliation, country | U. S. SISODIA, S. KHOTHARI and S. AMETA Pacific University, Udaipur, Rajasthan-313024, India |
3 | Subject | Dicipline(s) | Chemical Science |
3 | Subject | Keywords | Regioselectivity, Spiro-2-aminopyrimidinones-5-carbonitrile, Ionic liquid, Green solvent |
4 | Description | Abstract | An interesting regioselectivity was investigated for the synthesis of spiro-2-aminopyrimidinones-5-carbonitrile (4a-e) by the multicomponent condensation of cyclic ketones (1a-d) , alkyl cyanoacetates (2) and various guanidine salts (3) using 3-butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate ([BMIM][BF4]) as ionic liquid. Existence of two possible potentially active centers i.e. -CN and ?COOR groups in the intermediate to Michael adduct results in possibility of formation of two region-isomeric products i.e. spiro-2-aminopyrimidinones-5-carbonitrile (4a-e) or spiro-2-amino-4-imino-pyrimidin-5-carboxylic acid alkyl ester (5). High regioselectivity was displayed with exclusive formation of compound (4a-e) which was further confirmed by spectral studies |
5 | Publishers | Organizing agency, location | WWW Publications, India |
6 | Contributor | Sponsor(s) | - |
7 | Date | Date (YYYY-MM-DD) | - |
8 | Type | Status & genre | Peer-reviewed Article |
8 | Type | Type | |
9 | Formate | File Formate | PDF |
10 | Identifier | Uniform Resource Identifier | Click Here |
10 | Identifier | Digital Object Identifier | |
11 | Source | Journal/conference title; vol., no. (Year) | Chemical Science Transactions, Volume 6 , Number (1), (2017) |
12 | Lanuguage | English=en | en |
13 | Relation | Supp.files | |
14 | Coverage | | - |
15 | Copyright | Copyright and permissions | |