| DUBLIN | CORE | METADATA ITEM | METADATA FOR THIS DOCUMENT |
| 1 | Title | Title of Document | Identification of Novel Triazole Based Indoles as Lead Molecules against Enzyme Mediated Inflammation |
| 2 | Creator | Author's name, affiliation, country | PARTEEK PRASHER
University of Petroleum and Energy Study, PO Bidholi, Uttrakhand, Dehradun- 248007, India |
| 3 | Subject | Dicipline(s) | Chemical Science |
| 3 | Subject | Keywords | 5LOX, COX-1/2, MIC, Inhibition, Isothermal titration calorimetry |
| 4 | Description | Abstract | A new set of compounds containing indole nucleus appended with carefully selected amino acids via atriazole linker are identified. These compounds are found to be effective against the enzymes responsible for inflammation. The in vitro enzyme immunoassay studies on the test compounds indicated substantial activities which become amplified for the compounds with free carboxyl group. The kinetic experiments indicated favourable enzyme-drug interactions with 1:1 stoichiometry being the most favoured. The in vivo experiments on these compounds indicated the acceptable limits of toxicity compared to the control. All these findings were in close coordination with the docking investigations |
| 5 | Publishers | Organizing agency, location | WWW Publications, India |
| 6 | Contributor | Sponsor(s) | - |
| 7 | Date | Date (YYYY-MM-DD) | - |
| 8 | Type | Status & genre | Peer-reviewed Article |
| 8 | Type | Type | |
| 9 | Formate | File Formate | PDF |
| 10 | Identifier | Uniform Resource Identifier | Click Here |
| 10 | Identifier | Digital Object Identifier | |
| 11 | Source | Journal/conference title; vol., no. (Year) | Chemical Science Transactions, Volume 5 , Number (4), (2016) |
| 12 | Lanuguage | English=en | en |
| 13 | Relation | Supp.files | |
| 14 | Coverage | | - |
| 15 | Copyright | Copyright and permissions | |
