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Synthesis and Antibacterial Screening of 4-Arylidene-5-oxo-imidazoles having Carboxamide Linkage with 5-(benzofuran-2-yl)-1-phenylpyrazole Moiety |
| DUBLIN | CORE | METADATA ITEM | METADATA FOR THIS DOCUMENT |
| 1 | Title | Title of Document | Synthesis and Antibacterial Screening of 4-Arylidene-5-oxo-imidazoles having Carboxamide Linkage with 5-(benzofuran-2-yl)-1-phenylpyrazole Moiety |
| 2 | Creator | Author's name, affiliation, country | MOHAMMAD IDREES* R. D. NASARE and N. J. SIDDIQUI
Department of Chemistry, Government Institute of Science,
Nagpur-440001, Maharashtra, India
Department of Chemistry, Government Science College,
Gadchiroli- 442605, Maharashtra, India
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| 3 | Subject | Dicipline(s) | Chemical Science |
| 3 | Subject | Keywords | 5-Oxo imidazole, 4-Arylidene oxazolones, Carbohydrazides |
| 4 | Description | Abstract | Synthesis of 5-(H/Br benzofuran-2-yl)-1-phenyl 1H-pyrazole-3-carbohydrazides (1a-b) and condensation with different 4-(arylidene)-2 phenyloxazol-5(4H)-one (2a-g) in acetic acid medium, a series of 5-(H/Br benzofuran -2-yl)-N-(4-arylidene-5-oxo-2-phenyl-4,5-dihydro-imidazol-1-yl)-1-phenyl-1H-pyrazole-3-carboxamide derivatives (3a-g) have been carried out. Different 4-(arylidene)-2-phenyloxazol-5(4H)-one (2a-g) were synthesized from substituted benzaldehyde with hippuric acid. The structures of the novel compounds were elucidated on the basis of elemental analysis and spectral studies such as FT-IR, 1H NMR, further supported by Mass spectra. The synthesized 5-(benzofuran-2-yl)-N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-1-phenyl-1H-pyrazole-3-carboxamide (3a) was assayed in vitro for their antimicrobial activity at different concentration against four different bacterial strains namely B. thurengienesis, S. aureus, E. Coli and E. Areogenes. The investigation of antibacterial screening reveals that 3a exhibited excellent activity against Gram +ve and poor activity against Gram ?ve bacteria when compared to chloramphenicol as standard drug |
| 5 | Publishers | Organizing agency, location | WWW Publications, India |
| 6 | Contributor | Sponsor(s) | - |
| 7 | Date | Date (YYYY-MM-DD) | - |
| 8 | Type | Status & genre | Peer-reviewed Article |
| 8 | Type | Type | |
| 9 | Formate | File Formate | PDF |
| 10 | Identifier | Uniform Resource Identifier | Click Here |
| 10 | Identifier | Digital Object Identifier | |
| 11 | Source | Journal/conference title; vol., no. (Year) | Chemical Science Transactions, Volume 5 , Number (4), (2016) |
| 12 | Lanuguage | English=en | en |
| 13 | Relation | Supp.files | |
| 14 | Coverage | | - |
| 15 | Copyright | Copyright and permissions | |
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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