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Chemical and Biological Studies on Some Pregnane Derivatives

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1TitleTitle of DocumentChemical and Biological Studies on Some Pregnane Derivatives
2CreatorAuthor's name, affiliation, country N. M. ABD EL-SALAM1* and G. A. AHMED2
1 Department of Natural Sciences, Riyadh Community College, King Saud University, P.O.Box 2455, Riyadh-11451, Saudi Arabia
2Chemistry Department, Faculty of Science, Zagazig University, Egypt
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Pyrimidine, Pyrazoline, Isoxazoline
4DescriptionAbstract Reaction of the pregnane derivatives (1), (2), (3) and (4) with hydrazines, afforded the pyrazoline derivatives, (5a,b), (6a,b), (7a, b) and (8a,b) respectively, compound (1) and (3) reacted with urea and thiourea and give pyrimidine and pyrimidinethione derivatives (9a,b) and (10a,b) respectively. Also, compound (1) reacted with hydroxylamine hydrochloride and guanidine carbonate in refluxing ethanol and yield the isoxazole derivative (11) and the aminopyrimidine (12). Evaluation of the biological activity of the synthesized compounds, were carried and they had a significant effects as antibiotics and gram positive bacteria and gram negative bacteria.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2012.133
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  1 , Number  (1), (2012)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
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