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Synthesis and Characterization of 1,3,4-Oxadiazoles Derivatives from 1,2,3,4-Tetrahydroisoquinoline and their Bioevalution (Antibacterial & Antifungal)

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1TitleTitle of DocumentSynthesis and Characterization of 1,3,4-Oxadiazoles Derivatives from 1,2,3,4-Tetrahydroisoquinoline and their Bioevalution (Antibacterial & Antifungal)
2CreatorAuthor's name, affiliation, country N. KRISHNA RAO1, M. SURENDRA BABU2*, M. V. BASAVESWARA RAO1, R. KESHAVI3, N. SUNDARA RAO3, Y. L. N. MURTHY3 and SHAIK LAKSHMAN4
1Chemistry Department, Krishna University, Machilipatnam, India
2Department of Chemistry, GITAM University, Hyderabad, India
3Department of Organic Chemistry, Andhra University, Visakhapatnam, India
4Department of Chemistry, GITAM University, Visakhapatnam, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords 1,2,3,4-Tetrahydroisoquinoline, Ethyl-2-(1-phenyl-3,4-dihydro isoquinoline-2(1H)-yl) acetate, 2-(1-Phenyl-3,4-dihydroisoqunoline-2(1H)-yl)acetohydrazide, 1,3,4-Oxadiazole, Cyclization re
4DescriptionAbstract New derivatives of 1,3,4-oxadiazole, synthesized by the condensation of different substituted benzoic acids with 2-(1-phenyl-3,4-dihydroisoquinoline-2(1H)-yl) acetohydrazide using SOCl2 as well as POCl3 as cyclization reagents. Ethyl-2-(1-phenyl-1,2,3,4-tetrahydroisoquinoline)-ethaonate was synthesized from 1,2,3,4-Tetrahydroisoquinoline and it was converted to the 2-(1-phenyl-3,4-dihydroisoquinoline-2(1H)-yl)acetohydrazide. This compound is the key intermediate for the 1,3,4-oxadiazole compounds. All the synthesized molecules were characterized by advanced spectral data and also studied their biological activity.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2017.1356
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  6 , Number  (3), (2017)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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