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Reaction of 4-Hydroxycoumarin with Salicylaldehyde: Products Formed Under Various Conditions and their Antiproliferative Activity

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1TitleTitle of DocumentReaction of 4-Hydroxycoumarin with Salicylaldehyde: Products Formed Under Various Conditions and their Antiproliferative Activity
2CreatorAuthor's name, affiliation, country SHAZIA MUZAFFAR BANDAY and KHALIQUZ ZAMAN KHAN
Department of Chemistry, University of Kashmir, Hazratbal, Srinagar, Jammu & Kashmir, 190006, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords 4-Hydroxycoumarin, Salicylaldehyde, Antiproliferation
4DescriptionAbstract The reaction of 4-hydroxycoumarin with salicylaldehyde was carried out in ethanol and water-ethanol mixture (2:1 v/v) using conventional and microwave assisted methods. The reactions were explored leading to the formation of a single product in contrast to the two products formed usually, viz. 3-(o-hydroxybenzal)-2,4-diketochroman and 3-[6-oxo(1)benzopyran (4,3-b)-(1) benzopyran-7-yl]-4-hydroxy-2H-chromen-2-one. In addition to the exclusive formation of a single product, the time of reaction was reduced considerably. The products were evaluated for their antiproliferative activity and were found to exhibit good activity in comparison to the 4-hydroxycoumarin moiety.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2017.1364
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  6 , Number  (2), (2017)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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