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Visible Spectrophotometric Determination of Metochlopramide Hydrochloride at Trace Levels in Various Samples after Cloud Point Extraction Using Derivatization Reaction

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1TitleTitle of DocumentVisible Spectrophotometric Determination of Metochlopramide Hydrochloride at Trace Levels in Various Samples after Cloud Point Extraction Using Derivatization Reaction
2CreatorAuthor's name, affiliation, country ZUHAIR A-A KHAMMAS* and HAWRAA M. ABDULKATEEM
Department of Chemistry, College of Science for Women, University of Baghdad, Jadiyriah, Baghdad, Iraq
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Metochlopramide hydrochloride, 8-Hydroxyquinoline, Phenylephrine hydrochloride, Diazotization-coupling reaction, Cloud point extraction, Visible- spectrophotometry
4DescriptionAbstract Two new methods have been established based on extraction and determination of drug metochlopramide hydrochloride (MCP.HCl) in different samples, by using surfactant as extracting medium and visible spectrophotometer as a detection system. The methods are depended on the reaction of diazonium MCP.HCl with (A) 8-hydroxyquinoline (8-HQ) and (B) phenylephrine hydrochloride (PHE) in alkaline media to form azo dyes products which can be extracted into micelles of triton x-114 and drug MCP.HCl determined in the visible region at λmax of 530 and 490 nm respectively. All parameters that influence on diazotization coupling reaction between the drug and reagents as well as for extraction efficiency of the colored products are examined by using the conventional optimization. The results have shown that the enrichment factors of 217.7 and 26.98 fold, achieving the detection limit of 0.019 and 0.24 μgmL-1, with linear range of 0.1-0.7 μgmL-1 (r = 0.9996) and 0.5-11.0 μgmL-1 (r=0.9998) for the drug MCP.HCl in method A and B respectively. The mean percent recovery was 98.20±2.71% in drug vial sample and 99.37±2.41 % in tap water and the precision (RSD%) ranged between 3.53-1.21% and 0.97-0.11% for MCP.HCl in method A and B, respectively. The developed methods were compared with reported methods published in chemical literature and used for the determination of MCP.HCl in different samples
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2017.1381
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  6 , Number  (4), (2017)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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