DUBLIN | CORE | METADATA ITEM | METADATA FOR THIS DOCUMENT |
1 | Title | Title of Document | Evaluation of In Vitro Anti-Inflammatory Activity for Novel Imine Derivatives from Acetylcoumarin by Catalyst-Free Green Solvent |
2 | Creator | Author's name, affiliation, country | P. N. BALAJI1*, K. C. LAVANYA1 and D. RANGANAYAKULU2 1Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy,
Tiruchanoor, Tirupati. A.P, India
2Department of Pharmacology, Sri Padmavathi School of Pharmacy,
Tiruchanoor, Tirupati. A.P, India
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3 | Subject | Dicipline(s) | Chemical Science |
3 | Subject | Keywords | Acetylcoumarin, Green solvent, Azomethine, Fries rearrangement, Ambient temperature |
4 | Description | Abstract | Facile method used in synthesis of some novel seven Schiff?s base (azomethine) compounds in catalytic free green solvent (i.e using glycerol) at ambient temperature from acetylcoumarin. Acetoxy coumarin are synthesized by acetylating from previously prepared 4-methyl-7-hydroxy coumarin with acetic anhydride from standard procedures, that was further heated in metallic catalyst to produce 8-acetly-7-hydroxy-4-methylcoumarin by fries re-arrangement. The obtain acetylcoumarin was reacted with different substituted arylamine in glycerol under catalytic free condition heated at 90 oC for 6 h to produce imine derived coumarin compounds. Compounds were recrystalised and its melting points were determined by digital apparatus which are un-correct. Structure of the compounds was characterized by FT-IR (KBr method) and 1H NMR for selected compounds. All the synthesized compounds were evaluated for in-vitro anti-inflammatory by standard procedure with slight revision. From the obtain data compounds shows substantial result compared to standard value |
5 | Publishers | Organizing agency, location | WWW Publications, India |
6 | Contributor | Sponsor(s) | - |
7 | Date | Date (YYYY-MM-DD) | - |
8 | Type | Status & genre | Peer-reviewed Article |
8 | Type | Type | |
9 | Formate | File Formate | PDF |
10 | Identifier | Uniform Resource Identifier | Click Here |
10 | Identifier | Digital Object Identifier | |
11 | Source | Journal/conference title; vol., no. (Year) | Chemical Science Transactions, Volume 6 , Number (3), (2017) |
12 | Lanuguage | English=en | en |
13 | Relation | Supp.files | |
14 | Coverage | | - |
15 | Copyright | Copyright and permissions | |