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Evaluation of In Vitro Anti-Inflammatory Activity for Novel Imine Derivatives from Acetylcoumarin by Catalyst-Free Green Solvent

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1TitleTitle of DocumentEvaluation of In Vitro Anti-Inflammatory Activity for Novel Imine Derivatives from Acetylcoumarin by Catalyst-Free Green Solvent
2CreatorAuthor's name, affiliation, country P. N. BALAJI1*, K. C. LAVANYA1 and D. RANGANAYAKULU2
1Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati. A.P, India
2Department of Pharmacology, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati. A.P, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Acetylcoumarin, Green solvent, Azomethine, Fries rearrangement, Ambient temperature
4DescriptionAbstract Facile method used in synthesis of some novel seven Schiff?s base (azomethine) compounds in catalytic free green solvent (i.e using glycerol) at ambient temperature from acetylcoumarin. Acetoxy coumarin are synthesized by acetylating from previously prepared 4-methyl-7-hydroxy coumarin with acetic anhydride from standard procedures, that was further heated in metallic catalyst to produce 8-acetly-7-hydroxy-4-methylcoumarin by fries re-arrangement. The obtain acetylcoumarin was reacted with different substituted arylamine in glycerol under catalytic free condition heated at 90 oC for 6 h to produce imine derived coumarin compounds. Compounds were recrystalised and its melting points were determined by digital apparatus which are un-correct. Structure of the compounds was characterized by FT-IR (KBr method) and 1H NMR for selected compounds. All the synthesized compounds were evaluated for in-vitro anti-inflammatory by standard procedure with slight revision. From the obtain data compounds shows substantial result compared to standard value
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2017.1390
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  6 , Number  (3), (2017)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
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