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Synthesis of 2-Amino-6-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-1-yl)-4-(substituted)- phenylpyridine-3-carbonitrile Derivatives and their Antibacterial and Antifungal Activity

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1TitleTitle of DocumentSynthesis of 2-Amino-6-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-1-yl)-4-(substituted)- phenylpyridine-3-carbonitrile Derivatives and their Antibacterial and Antifungal Activity
2CreatorAuthor's name, affiliation, country SHIV KUMAR* and DALBIR SINGH
Department of Pharmacy, Government Polytechnic, Uttawar, Palwal-121103, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Quinoxaline, Pyridine, Antibacterial, Antifungal
4DescriptionAbstract Fifteen compounds belonging to chemical series 2-amino-6-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-1-yl)-4-(substituted)phenylpyridine-3-carbonitrile (3a-o) were synthesized by a multistep scheme and evaluated for their in vitro antibacterial and antifungal activities against bacterial strains E. coli, S. aureus, P. aeruginosa, K. pneumonia and antifungal activity against fungal strains A. niger, C. albicans and A. flavus by cup-plate diffusion method. Structures of all the newly synthesized compounds were confirmed by FT-IR, 1H NMR and ESI-MS spectral data interpretation and elemental analysis. Compounds 3e, 3k, 3l, 3m and 3n having functional groups viz. 4-CF3, 4-NO2, 2-F, 2-NO2, 4-F respectively on phenyl ring attached to position-4 of pyridine ring attached to N-1 of (1H,4H)quinoxaline-2,3-dione exhibited better antibacterial and antifungal activities against all the bacterial and fungal strains under investigation.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2017.1396
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  6 , Number  (3), (2017)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
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