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Synthesis, Spectral Characterization and Antimicrobial Activities of Ethyl-2-(4-(naphthalene-1-yl)-6-phenyl- pyrimidin-2-yl amino)acetate Derivatives |
| DUBLIN | CORE | METADATA ITEM | METADATA FOR THIS DOCUMENT |
| 1 | Title | Title of Document | Synthesis, Spectral Characterization and Antimicrobial Activities of Ethyl-2-(4-(naphthalene-1-yl)-6-phenyl- pyrimidin-2-yl amino)acetate Derivatives |
| 2 | Creator | Author's name, affiliation, country | C. RAJA1, M R. EZHILARASI1*, B. PRABHA1 and M. KULANDHAIVEL2
1Department of Chemistry, Karpagam University, Coimbatore-21, Tamilnadu, India
2Department of Micro-Biology, Karpagam University, Coimbatore-21, Tamilnadu, India
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| 3 | Subject | Dicipline(s) | Chemical Science |
| 3 | Subject | Keywords | Naphthalene chalcone, Chloroethyl acetate, Guanidine nitrate, K2 CO3 Antimicrobial activity |
| 4 | Description | Abstract | The novel series of ethyl-2-(4-naphthalene-1-yl)-6-phenyl pyrimidin-2-yl amino)acetate derivatives were synthesised by the condensation reactions of 4-(naphthalene-1-yl)-6-phenyl pyrimidin-2-amines reacted with chloroethyl acetate and K2CO3 as a catalyst.
The 4-(naphthalene-1-yl)-6-phenyl pyrimidin-2-amines were occurred by the reaction between naphthalene chalcones and guanidine nitrate in the presence of ethanolic sodium hydroxide solution. The naphthalene chalcones were synthesised from substituted aldehydes treated with 1-acetyl naphthalene. Finally the synthesised compounds were determined by elemental analysis and spectral characterizations such as FT-IR, 1H NMR and 13C NMR. The antimicrobial activities of the new synthesised heterocyclic compound are evaluated against gram positive, gram negative bacterial and fungal strains. The electron withdrawing chloro substituted derivative have an excellent zone of inhibition against bacterial strains.
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| 5 | Publishers | Organizing agency, location | WWW Publications, India |
| 6 | Contributor | Sponsor(s) | - |
| 7 | Date | Date (YYYY-MM-DD) | - |
| 8 | Type | Status & genre | Peer-reviewed Article |
| 8 | Type | Type | |
| 9 | Formate | File Formate | PDF |
| 10 | Identifier | Uniform Resource Identifier | Click Here |
| 10 | Identifier | Digital Object Identifier | |
| 11 | Source | Journal/conference title; vol., no. (Year) | Chemical Science Transactions, Volume 6 , Number (4), (2017) |
| 12 | Lanuguage | English=en | en |
| 13 | Relation | Supp.files | |
| 14 | Coverage | | - |
| 15 | Copyright | Copyright and permissions | |
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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