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Synthesis, Spectral Characterization and Antimicrobial Activities of Ethyl-2-(4-(naphthalene-1-yl)-6-phenyl- pyrimidin-2-yl amino)acetate Derivatives

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1TitleTitle of DocumentSynthesis, Spectral Characterization and Antimicrobial Activities of Ethyl-2-(4-(naphthalene-1-yl)-6-phenyl- pyrimidin-2-yl amino)acetate Derivatives
2CreatorAuthor's name, affiliation, country C. RAJA1, M R. EZHILARASI1*, B. PRABHA1 and M. KULANDHAIVEL2
1Department of Chemistry, Karpagam University, Coimbatore-21, Tamilnadu, India
2Department of Micro-Biology, Karpagam University, Coimbatore-21, Tamilnadu, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Naphthalene chalcone, Chloroethyl acetate, Guanidine nitrate, K2 CO3 Antimicrobial activity
4DescriptionAbstract The novel series of ethyl-2-(4-naphthalene-1-yl)-6-phenyl pyrimidin-2-yl amino)acetate derivatives were synthesised by the condensation reactions of 4-(naphthalene-1-yl)-6-phenyl pyrimidin-2-amines reacted with chloroethyl acetate and K2CO3 as a catalyst. The 4-(naphthalene-1-yl)-6-phenyl pyrimidin-2-amines were occurred by the reaction between naphthalene chalcones and guanidine nitrate in the presence of ethanolic sodium hydroxide solution. The naphthalene chalcones were synthesised from substituted aldehydes treated with 1-acetyl naphthalene. Finally the synthesised compounds were determined by elemental analysis and spectral characterizations such as FT-IR, 1H NMR and 13C NMR. The antimicrobial activities of the new synthesised heterocyclic compound are evaluated against gram positive, gram negative bacterial and fungal strains. The electron withdrawing chloro substituted derivative have an excellent zone of inhibition against bacterial strains.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2017.1403
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  6 , Number  (4), (2017)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
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