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Novel Method for the Quantification of Ropinirole Hydrochloride in Pure API and its Marketed Formulations Using 3-Methyl-2-benzothiazolinone Hydrazone Hydrochloride and p-Dimethylaminocinnamaldehyde as Chromogenic Reagents by Spectrophotometry |
| DUBLIN | CORE | METADATA ITEM | METADATA FOR THIS DOCUMENT |
| 1 | Title | Title of Document | Novel Method for the Quantification of Ropinirole Hydrochloride in Pure API and its Marketed Formulations Using 3-Methyl-2-benzothiazolinone Hydrazone Hydrochloride and p-Dimethylaminocinnamaldehyde as Chromogenic Reagents by Spectrophotometry |
| 2 | Creator | Author's name, affiliation, country | I. SRIKANTH1*, M. SRILATHA1, P. RATNA KUMARI1, P. V. SURESH2
1Department of Pharmaceutical Analysis, K.C. Reddy Institute of Pharmaceutical Sciences, Jangamguntla Palem, Medikonduru Mandal, Guntur 522 348, India
2Department of Pharmaceutical Analysis, Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam, Guntur 522 034, India
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| 3 | Subject | Dicipline(s) | Chemical Science |
| 3 | Subject | Keywords | Chromogen, MBTH, PDAC, Ropinirole hydrochloride, Spectrophotometry |
| 4 | Description | Abstract | Two novel simple and sensitive spectrophotometric methods in visible region were developed for the estimation of ropinirole hydrochloride (RPH) in pure and its pharmaceutical dosage forms. Method-A based on the oxidative coupling product with 3-methyl-2-benzothiazolinone bydrazone bydrochloride (MBTH) in presence of ferric chloride to give intense blue colored azodye complex having λmax at 680 nm and method-B based on the reaction of p-dimethylamino cinnamaldehyde (PDAC) under acidic media to give yellow colored Schiff base having λmax at 420 nm. Both these methods obey Beers law in the concentration range of 5-50 μg/mL. All variables in these methods are optimized and the reaction mechanisms are presented. No interference was observed from tablet additives and the applicability of these methods was examined by analyzing tablets containing RPH. The proposed methods are precise, accurate and reproducible. It can be extended to the analysis of ropinirole hydrochloride in marketed formulations. |
| 5 | Publishers | Organizing agency, location | WWW Publications, India |
| 6 | Contributor | Sponsor(s) | - |
| 7 | Date | Date (YYYY-MM-DD) | - |
| 8 | Type | Status & genre | Peer-reviewed Article |
| 8 | Type | Type | |
| 9 | Formate | File Formate | PDF |
| 10 | Identifier | Uniform Resource Identifier | Click Here |
| 10 | Identifier | Digital Object Identifier | |
| 11 | Source | Journal/conference title; vol., no. (Year) | Chemical Science Transactions, Volume 6 , Number (4), (2017) |
| 12 | Lanuguage | English=en | en |
| 13 | Relation | Supp.files | |
| 14 | Coverage | | - |
| 15 | Copyright | Copyright and permissions | |
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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