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Synthesis, Characterization and In Vitro Antibacterial Effect of 4H-Benzo[g]chromene Derivatives using Nano-NiO

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1TitleTitle of DocumentSynthesis, Characterization and In Vitro Antibacterial Effect of 4H-Benzo[g]chromene Derivatives using Nano-NiO
2CreatorAuthor's name, affiliation, country T. CLARINA, G. R. PRIYA DHARSINI and V. RAMA*
Department of Chemistry, Sarah Tucker College, Manonmaniam Sundarnar University, Abishekapatti, Tirunelveli -627 012, Tamilnadu, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Antibacterial, Knoevenagel condensation, Michael cyclization, Nano-NiO, Simple workup
4DescriptionAbstract The domino Knoevenagel cyclocondensation reactions via substituted aldehydes, activated methylene reagent and 2-hydroxy-1, 4-naphthoquinone gives benzo[g]chromenes in presence of nano-NiO using acetonitrile as a solvent at ambient temperature. This method gives the desired products from good to excellent yield. The salient features of this atom economical procedure are ease of manipulation, simpler workup, high yield processing, easy handling, inexpensiveness, reusability of catalyst and tolerance to a wide range of functional groups. The synthesized chromene derivatives are screened for antibacterial activity and antifungal activity using Kirby-Bauer method. The synthesized compounds 3a-3k exhibits significant inhibition to antibacterial and antifungal activity compared with the standard drug Ciprofloxacin and Flucanazole respectively.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  6 , Number  (4), (2017)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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