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Synthesis, Characterization, Chemical Nuclease Activity and Antimicrobial Evaluation of Tridentate (NOS Donor) Schiff Base Ligand: 2-(4-(Thiophen-2-yl)but-3-en-2-ylideneamino)phenol and their Metal-Organic Hybrids

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1TitleTitle of DocumentSynthesis, Characterization, Chemical Nuclease Activity and Antimicrobial Evaluation of Tridentate (NOS Donor) Schiff Base Ligand: 2-(4-(Thiophen-2-yl)but-3-en-2-ylideneamino)phenol and their Metal-Organic Hybrids
2CreatorAuthor's name, affiliation, country G. R. PRIYA DHARSINI, T. CLARINA and V. RAMA*
Department of Chemistry, Sarah Tucker College, Manonmaniam Sundarnar University, Abishekapatti, Tirunelveli ? 627 012, Tamilnadu, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Antimicrobial, DNA cleavage, Schiff base, Tridentate, Thiophene
4DescriptionAbstract Cu(II), Co(II), Ni(II) and Zn(II) metal-organic hybrids of new tridentate (NOS donor) Schiff base ligand derived from 4-(thiophen-2-yl)but-3-en-2-one (TB) and 2-aminophenol (AP) were synthesized, characterized and their pharmacological activities were evaluated. Possible geometry of the hybrid derivatives and the chelating atoms were investigated on the source of elemental analysis, magnetic moment, molar conductivity, infrared, EPR, NMR, electronic and mass spectral studies. The results were consistent with a three coordination environment around the metal ion. Synthesized compounds were screened for in vitro antimicrobial activity against bacteria Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, Staphylococcus aureus, Staphylococcus saprophyticus and fungi Candida albicans. Hybrid derivatives showed improved antibacterial and antifungal activity compared with the ligand 2(-4-(thiophen-2-yl)but-3-en-2-ylidene amino)phenol (TBAP). DNA cleavage experiments done by means of gel electrophoresis with corresponding hybrid derivatives in the presence of H2O2 showed pronounced discernible DNA cleavage.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2017.1423
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  6 , Number  (4), (2017)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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