| DUBLIN | CORE | METADATA ITEM | METADATA FOR THIS DOCUMENT |
| 1 | Title | Title of Document | Drug Metal Ion Interaction: Kinetics and Mechanism of Interaction of cis-Bis(oxalato)diaquochromium(III) Ion with Ampicillin in Aqueous Medium |
| 2 | Creator | Author's name, affiliation, country | BHARATI BEHERA and JASHODA BEHERA*
Department of Chemistry, Utkal University,
Vani Vihar, Bhubaneswar-751004, Odisha, India
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| 3 | Subject | Dicipline(s) | Chemical Science |
| 3 | Subject | Keywords | Cr(III)complex, Ampicillin, Substitution reaction, Kinetic study, Elemental analysis, Antimicrobial activity |
| 4 | Description | Abstract | The kinetics of anation of cis-[Cr(C2O4) 2 (H2O) 2]- by ampicillin have been investigated in aqueous medium over the range 3.0 ≤ pH ≤ 5.0, 1.50x10-2mol dm-3 ≤ [AMP] ≤ 4.50x10-2 mol dm-3, I = 0.3 mol dm-3 (KNO3) and at temperature 35 oC ≤ t ≤ 50 oC. The reaction takes place through an Ia mechanism. The rate of reaction is found to increase with increase in [H+] and [AMP-Na]. The activation parameters ΔH≠ and ΔS≠ are found to be 42.4±2.5 and -176.6±8.1 respectively. The negative values of activation entropies (ΔS≠) indicate a more ordered activated complex than the reactants and the reactions are slow. The positive values of activation enthalpy (ΔH≠) shows that the decomposition process is endothermic. The product was isolated as [Cr2 (C2O4)4 (AMP)].2H2O which was confirmed by FTIR and AAS method. The antimicrobacterial activities of the complex was tested against some kind of bacteria comparable with the ampicillin free drug. |
| 5 | Publishers | Organizing agency, location | WWW Publications, India |
| 6 | Contributor | Sponsor(s) | - |
| 7 | Date | Date (YYYY-MM-DD) | - |
| 8 | Type | Status & genre | Peer-reviewed Article |
| 8 | Type | Type | |
| 9 | Formate | File Formate | PDF |
| 10 | Identifier | Uniform Resource Identifier | Click Here |
| 10 | Identifier | Digital Object Identifier | |
| 11 | Source | Journal/conference title; vol., no. (Year) | Chemical Science Transactions, Volume 6 , Number (4), (2017) |
| 12 | Lanuguage | English=en | en |
| 13 | Relation | Supp.files | |
| 14 | Coverage | | - |
| 15 | Copyright | Copyright and permissions | |
