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Novel Phenyl and Purine Substituted Derivatives of Quinazolinones: Synthesis, Antioxidant and Antibacterial Features

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1TitleTitle of DocumentNovel Phenyl and Purine Substituted Derivatives of Quinazolinones: Synthesis, Antioxidant and Antibacterial Features
2CreatorAuthor's name, affiliation, country NAGARAJA NAIK* and JAVARAPPA RANGASWAMY
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore -570006, Karnataka, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Novel phenyl and purine substituted derivatives of quinazolinones, Antioxidant, Antibacterial activity
4DescriptionAbstract A one-pot three-component protocol for the preparation of novel phenyl and purine substituted derivatives of quinazolinones through the reaction of 7H-purin-6-amine, cyclohexane-1,3-diketone and aromatic aldehydes in acetic acid is reported. A broad range of quinazolinones were obtained in 55−82% overall yield. In this article, we describe the identification of the good oxidation inhibitors (IC50 values of 13, 16, 22 and 25 μM, respectively). Compounds IVf and IVg exhibited excellent in vitro radical inhibition activity against a DPPH radical, providing new opportunities for the series. In vitro antibacterial activity toward bacterial strain was also examined, compounds IVb, IVc and IVi exhibits stronger bacterial activity. Overall, the obtained results suggest that further optimization of activity of the series could provide a strong lead for a new antioxidant and antibacterial drug development program.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  7 , Number  (1), (2018)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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