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HPLC Method Development for Estimation of Dissolution of Antipsychotic Drug as Sublingual Film Dosage Form

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1TitleTitle of DocumentHPLC Method Development for Estimation of Dissolution of Antipsychotic Drug as Sublingual Film Dosage Form
2CreatorAuthor's name, affiliation, country KIRAN PATEL1, DEEPKUMAR JOSHI1, JASMIN KUMBHANI2 and VIPUL PRAJAPATI1*
1Chemistry Research Laboratory, Sheth M. N. Science College, Patan-384265, India
2Chemistry Research Laboratory, PSSHDA, Kadi-382715, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Asenapine dimaleate, High performance liquid chromatography, Novel dosage form, Sublingual film, Dissolution
4DescriptionAbstract A simple, accurate, precise and specific reversed phase high performance liquid chromatography method was developed for the quantitative determination of antipsychotic drug Asenapine maleate in a novel dosage sublingual film form. A phenomenex C18, 5 μm column having 250?4.6 mm (internal diameter) in isocratic mode, with mobile phase containing water : methanol (60:40, v/v) was used. The flow rate was 1.0 mL min−1 and effluents were monitored at 231 nm. The retention time of asenapine was 4.54 min. The developed method was checked for assay of Asenapine sublingual film using different composition of dosage form. The method was successfully applied to the estimation of Asenapine in sublingual film dosage form.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2018.1495
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  7 , Number  (3), (2018)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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