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Synthesis and Bioevaluation Study of Benzofuran Linked Tetralones as Antimitotic Agent

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1TitleTitle of DocumentSynthesis and Bioevaluation Study of Benzofuran Linked Tetralones as Antimitotic Agent
2CreatorAuthor's name, affiliation, country B. UMESHA1, A. SOWBHAGY2 and Y. B. BASAVARAJU1*
1Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore - 570006, Karnataka, India
2Department of Studies in Organic Chemistry, University of Mysore, Manasagangotri, Mysore - 570006, Karnataka, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Chalcones, Substituted bezaldehyde, Onion root tip method, Antimitotic activity
4DescriptionAbstract A series of new benzofuran linked tetralones (5a-h) have been prepared by chalcone route of Claisen-Schmidt condensation reaction in the presence of sodium hydroxide, 1-(benzofuran-6-yl)-ethanone (1) reacts with substituted benzaldehyde (2a-h) followed by cyclopropanation of 1-(benzofuran-6-yl)-3-phenylprop-2-en-1-one (3a-h) with trimethylsulfoxonium iodide (TMSOI) in the presence of sodium hydride and Friedel-Craft?s intramolecular cyclization reaction of benzofuran-6-yl(2-phenylcyclopropyl)methanone (4a-h) in the presence of anhyd. stannic chloride and acetic anhydride. The target molecules were characterized by spectral and elemental analysis and also screened for their antimitotic activity by onion root method. Taken together, our results indicated that among the entire synthesized analogues, the two new compounds 5e and 5f bearing electron donating methoxy group on para and 3,4,5-position of the phenyl moiety respectively exhibits even good antimitotic activity than other compounds.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2018.1522
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  7 , Number  (4), (2018)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
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