Indexing Metadata
Synthesis and Biological Evaluation of Urea Derivatives of Combretastatins as Anticancer Agents |
| DUBLIN | CORE | METADATA ITEM | METADATA FOR THIS DOCUMENT |
| 1 | Title | Title of Document | Synthesis and Biological Evaluation of Urea Derivatives of Combretastatins as Anticancer Agents |
| 2 | Creator | Author's name, affiliation, country | V. RAMESH1, G. PURNA CHANDER RAO1,
B. CHAKRAPANI1 and A. KALYAN CHAKRAVARTHY2*
1Department of Chemistry, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India
2Dr. Reddy's Laboratories, Integrated Product Development, Bachupally, Hyderabad, India
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| 3 | Subject | Dicipline(s) | Chemical Science |
| 3 | Subject | Keywords | Combretastatin A-4, Sorafenib, Linifanib, Anticancer activity |
| 4 | Description | Abstract | A series of new combretastatin urea derivatives (12a-j) were synthesized by reacting of substituted aromatic isocyanates (11a-j) to the combretastatin pyrazole-amine. The synthesized derivatives 11a-j were evaluated for their cytotoxicity against four human cancer cell lines (breast, lung and ovarian). Among them, compounds 12a, 12c, 12d, 12f, 12g and 12i were showed potent anticancer activity. |
| 5 | Publishers | Organizing agency, location | WWW Publications, India |
| 6 | Contributor | Sponsor(s) | - |
| 7 | Date | Date (YYYY-MM-DD) | - |
| 8 | Type | Status & genre | Peer-reviewed Article |
| 8 | Type | Type | |
| 9 | Formate | File Formate | PDF |
| 10 | Identifier | Uniform Resource Identifier | Click Here |
| 10 | Identifier | Digital Object Identifier | |
| 11 | Source | Journal/conference title; vol., no. (Year) | Chemical Science Transactions, Volume 7 , Number (4), (2018) |
| 12 | Lanuguage | English=en | en |
| 13 | Relation | Supp.files | |
| 14 | Coverage | | - |
| 15 | Copyright | Copyright and permissions | |
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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