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Design, Synthesis and Biological Evaluation of Some Novel Chalcone-Sulfonamide Hybrids

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1TitleTitle of DocumentDesign, Synthesis and Biological Evaluation of Some Novel Chalcone-Sulfonamide Hybrids
2CreatorAuthor's name, affiliation, country MAHAMMADALI KHANUSIYA* and ZAKIRHUSEN GADHAWALA
Department of Chemistry, The HNSB Ltd Science College, Himatnagar, Gujarat, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Chalcones, Sulphonamide scaffold, Antibacterial, Antifungal
4DescriptionAbstract A series of novel chalcone tethered sulphonamide hybrids 3a-5f were fabricated by condensing appropriate sulphonamide scaffold with methoxy and/or hydroxy substituted chalcones as a multi-target drug for therapeutic treatment. Chalcones were prepared by Claisen-Schmidt condensation of a substituted aldehyde with para aminoacetophenone. The synthesized chalcone-sulphonamide hybrids were screened by means of their antibacterial activity by NCCLS method. Among all these compounds, 5e and 5c were observed to displaying more potent growth inhibitory activity against bacterial strain and hybrid 5a shows more obvious antifungal activity. FT-IR, NMR and HR-LCMS spectral study assert the structures of synthesized sulphonamide - chalcone hybrids.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2019.1538
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  8 , Number  (2), (2019)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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